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(3β,24S)-Cholest-5-ene-3,24-diol

(3β,24S)-Cholest-5-ene-3,24-diol 구조식 이미지

카스 번호:: 474-73-7

상품명:: (3β,24S)-Cholest-5-ene-3,24-diol

동의어(영문):: 24-hydroxycholesterol;24(S)-HYDROXYCHOLESTEROL;5-CHOLESTEN-3β, 24(S)-DIOL;cholest-5-ene-3β,24(S)-diol;(24S)-24-hydroxycholesterol;cholest-5-ene-3-beta,24-diol;(3β,24S)-Cholest-5-ene-3,24-diol;(3β,24S)-Cholest-5-ene-3,24-diol;Cholest-5-ene-3,24-diol, (3β,24S)-;24(S)-hydroxycholesterol (24(S)-HC)

CBNumber:: CB6498177

분자식:: C27H46O2

포뮬러 무게:: 402.65

MOL 파일:: 474-73-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 49

(3β,24S)-Cholest-5-ene-3,24-diol 속성

녹는점: 174-176 °C

끓는 점: 513.1±23.0 °C(Predicted)

밀도: 1.03±0.1 g/cm3(Predicted)

저장 조건: -20°C

용해도: DMSO(최대 10mg/ml) 또는 에탄올(최대 10mg/ml)에 용해됩니다.

물리적 상태: 가루

산도 계수 (pKa): 15.03±0.70(Predicted)

색상: 흰색에서 베이지색

optical activity: [α]/D -45 to -52°, c = 1 in chloroform-d

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 2개월 동안 보관할 수 있습니다.

안전

(3β,24S)-Cholest-5-ene-3,24-diol C화학적 특성, 용도, 생산

개요

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver. 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC₅₀ = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes. In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.

용도

(3β,24S)-Cholest-5-ene-3,24-diol is used as a biomarker in the analysis of disease.

일반 설명

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.

(3β,24S)-Cholest-5-ene-3,24-diol 준비 용품 및 원자재

원자재

준비 용품

(3β,24S)-Cholest-5-ene-3,24-diol 공급 업체

글로벌( 49)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7892	56

(3β,24S)-Cholest-5-ene-3,24-diol 관련 검색:

Thapsigargin Endosidin 2 SALUBRINAL U 18666A 1-Hexene Sodium cholate Inositol Aminophylline 24(S),25-Epoxycholesterol (not deuterated) 24(S),25-EPOXYCHOLESTEROL (3β,24S)-Cholest-5-ene-3,24-diol HYDROXYCHOLESTEROL 24(S), [24-3H]