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보수티닙

보수티닙
보수티닙 구조식 이미지
카스 번호:
380843-75-4
한글명:
보수티닙
동의어(한글):
보수티닙
상품명:
Bosutinib
동의어(영문):
CS-311;SKI-606;Bsutinib;BOSUTINIB;WAY-173606;Bosutinib control;Bosutinib(TINIBS );Bosulif(bosutinib);SKI 606 - Bosutinib;Bosutinib USP/EP/BP
CBNumber:
CB6504575
분자식:
C26H29Cl2N5O3
포뮬러 무게:
530.45
MOL 파일:
380843-75-4.mol

보수티닙 속성

녹는점
116-120 ºC
끓는 점
649.7±55.0 °C(Predicted)
밀도
1.36
저장 조건
room temp
용해도
DMSO: ≥15mg/mL
산도 계수 (pKa)
7.63±0.10(Predicted)
물리적 상태
powder
색상
off-white to light brown
InChIKey
PICKMQXYAMDEPF-UHFFFAOYSA-N
CAS 데이터베이스
380843-75-4(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36
안전지침서 26
WGK 독일 3
HS 번호 29335990
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H413 장기적 영향에 의해 수생생물에 유해의 우려가 있음 수생 환경유해성 물질 - 만성 구분 4
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

보수티닙 C화학적 특성, 용도, 생산

개요

In September 2012, the US FDA approved bosutinib (also referred to as SKI-607) for the treatment of relapsed or refractory chronicmyeloid leukemia (CML) for patients with resistance or intolerance to prior therapy. The National Cancer Institute estimates that in 2012, 5430 men and women were diagnosed with CML and 610 died of CML. First and second-line therapies for the treatment of CML include imatinib, dasatinib, and nilotinib. Bosutinib, which was initially identified as a Src inhibitor, was later found to be a dual inhibitor of Bcr–Abl (IC50=1.4 nM) and Src family kinases (IC50=3.5 nM). Bosutinib inhibits 16 of 18 imatinib-resistant forms of Bcr–Abl expressed in murine myeloid cell lines. In preclinical in vivo studies, bosutinib at 15 mg/kg administered orally for 5 days caused regression of K562 CML tumors in nude mice and in BaF3 tumors expressing wild type or different imatinib-resistant Bcr–Abl mutants at varying doses. A manufacturing process for the synthesis of bosutinib monohydrate has been reported that employs a key three-component cyclization reaction involving an aniline, a cyanoacetamide intermediate, and triethyl orthoformate followed by cyclization using phosphorous oxytrichloride and an optimized hydration procedure.

화학적 성질

Pale Yellow Solid

Originator

Wyeth (United States)

용도

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

용도

A novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.

용도

peripheral vasolidator increases cerebral blood flow, potential therapeutic for Altzheimer’s disease, cognitive impairment and dementia

정의

ChEBI: An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.

상표명

Bosulif

보수티닙 준비 용품 및 원자재

원자재

준비 용품


보수티닙 공급 업체

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AFINE CHEMICALS LIMITED
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26751 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58

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