수베로히드록사민산

수베로히드록사민산
수베로히드록사민산 구조식 이미지
카스 번호:
38937-66-5
한글명:
수베로히드록사민산
동의어(한글):
수베로히드록사민산
상품명:
Suberohydroxamic acid
동의어(영문):
ODHA;SBHA;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid;SUBEROYL BISHYDROXAMIC ACID
CBNumber:
CB6673028
분자식:
C8H16N2O4
포뮬러 무게:
204.22
MOL 파일:
38937-66-5.mol
MSDS 파일:
SDS

수베로히드록사민산 속성

녹는점
153-155 °C(lit.)
밀도
1.219±0.06 g/cm3(Predicted)
저장 조건
−20°C
용해도
H2O: 용해성
산도 계수 (pKa)
9.18±0.20(Predicted)
물리적 상태
동결건조된 분말
색상
흰색~밝은 베이지
안정성
흡습성

안전

안전지침서 22-24/25
WGK 독일 3
HS 번호 2928009090

수베로히드록사민산 C화학적 특성, 용도, 생산

개요

Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.

용도

Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.

생물학적 활성

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.

수베로히드록사민산 준비 용품 및 원자재

원자재

준비 용품


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