3,4-Diaminopyridine
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3,4-Diaminopyridine 속성
- 녹는점
- 216-218 °C (lit.)
- 끓는 점
- 194.6°C (rough estimate)
- 밀도
- 1.1118 (rough estimate)
- 굴절률
- 1.5340 (estimate)
- 인화점
- 240 °C
- 저장 조건
- Store below +30°C.
- 용해도
- 30g/L
- 산도 계수 (pKa)
- 9.17±0.12(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 갈색~갈색회색
- 수용성
- 24 g/L (20 ºC)
- Merck
- 14,2986
- BRN
- 110232
- CAS 데이터베이스
- 54-96-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T+,T,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-26-36/37/38 | ||
| 안전지침서 | 26-28-36/37/39-45-37/39-28A-36 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 2 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | US7600000 | ||
| F 고인화성물질 | 10-23 | ||
| 자연 발화 온도 | 480 °C | ||
| 위험 참고 사항 | Irritant | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | I | ||
| HS 번호 | 29333999 | ||
| 독성 | LD50 orally in Rabbit: 47 mg/kg LD50 dermal Rabbit > 200 mg/kg |
3,4-Diaminopyridine C화학적 특성, 용도, 생산
화학적 성질
brownish to brown-grey crystalline powder용도
It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.Indications
3,4-diaminopyridine has been used to treat Lambert Eaton myasthenia (LEM) for thirty years despite the lack of conclusive evidence of efficacy.Lambert–Eaton myasthenic syndrome is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction, which result from impaired release of acetylcholine from cholinergic nerve terminals. It is frequently associated with cancer, it is autoimmune-mediated, and treatment has been unsatisfactory.
The drug 3,4-diaminopyridine (3,4-DAP) increases neurotransmitter release and also the action potential (by blocking potassium conductance); these actions lead to a nonspecific excitatory effect on the cholinergic system, and provide benefit. It should be taken orally, 4-5 times per day. Adverse effects due to CNS excitation (insomnia, seizures) can occur.
Purification Methods
It crystallises from *benzene and is stored under N2 because it is deliquescent and absorbs CO2. [Beilstein 22/11 V 266.]3,4-Diaminopyridine 준비 용품 및 원자재
원자재
준비 용품
3,4-Diaminopyridine 공급 업체
글로벌( 420)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
3,4-Diaminopyridine 관련 검색:
2-아미노피리딘 3-아미노피리딘 4-다이메틸아미노피리딘 2,3-디아미노-5-브로모피리딘 펜아조피리딘 수화염화물
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4-AMINO-3-NITROQUINOLINE
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3,4-DIAMINOQUINOLINE
2,4-DIAMINOPYRIDINE
4-Amino-3-nitropyridine
Oxifungin
Elbanizine
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2-CHLORO-N4-METHYLPYRIDINE-3,4-DIAMINE