프레드니손
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프레드니손 속성
- 녹는점
- 236-238 °C(lit.)
- 알파
- 169 º (c=0.5, dioxane)
- 끓는 점
- 410.86°C (rough estimate)
- 밀도
- 1.1121 (rough estimate)
- 굴절률
- 170 ° (C=0.5, Dioxane)
- 인화점
- >200℃
- 저장 조건
- 2-8°C
- 용해도
- 물에는 거의 녹지 않으며, 에탄올(96%)과 염화메틸렌에는 약간 녹습니다. 다형성(5.9)을 보여줍니다.
- 산도 계수 (pKa)
- 12.36±0.60(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- 수용성
- 115mg/L(25℃)
- Merck
- 7722
- BRN
- 2065301
- BCS Class
- 1?
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- CAS 데이터베이스
- 53-03-2(CAS DataBase Reference)
- IARC
- 3 (Vol. 26, Sup 7) 1987
- NIST
- Prednisone(53-03-2)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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안전지침서 | 36/37/39-45-26-16 | ||
유해 물질 데이터 | 53-03-2(Hazardous Substances Data) | ||
기존화학 물질 | KE-10857 |
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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프레드니손 C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder.용도
Prednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.정의
ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.Indications
Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.일반 설명
Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.공기와 물의 반응
Very slightly water soluble .위험도
Questionable carcinogen.Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.Purification Methods
Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]프레드니손 준비 용품 및 원자재
원자재
준비 용품
프레드니손 공급 업체
글로벌( 450)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Han Sheng New Material Technology Co.,Ltd | +8617798174412 |
admin01@hsnm.com.cn | China | 2118 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 |
Nancy@kangcang.com.cn | China | 341 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9308 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
프레드니손 관련 검색:
코르티존 프레드니솔원 히드로코르티손 프레드니솔론-21-아세트산 숙신산메틸프레드니졸론나트륨 덱사메타손 아세트산, 무수물 프레드니손
PREDNISONE SODIUM PHOSPHATE
Hydrocortisone sodium succinate
Fludrocortisone
Hydrocortisone-17-butyrate
Prednisolone sodium succinate
Methylprednisolone
prednisone 21-acetate,PREDNISONE ACETATE
Methylprednisolone acetate
Pregna-1,4-diene-3,11,20-trione, 17-hydroxy-21-(phosphonooxy)-, disodium salt
PREDNISONE HEMISUCCINATE:HISTAMINE
chloroprednisone 21-acetate