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프레드니손

프레드니손
프레드니손 구조식 이미지
카스 번호:
53-03-2
한글명:
프레드니손
동의어(한글):
프레드니손
상품명:
Prednisone
동의어(영문):
MOPP;u6020;Cortan;Deltra;Cotone;deltae;U 6020;Wojtab;delta-E;In-Sone
CBNumber:
CB6716222
분자식:
C21H26O5
포뮬러 무게:
358.43
MOL 파일:
53-03-2.mol

프레드니손 속성

녹는점
236-238 °C(lit.)
알파
169 º (c=0.5, dioxane)
끓는 점
410.86°C (rough estimate)
밀도
1.1121 (rough estimate)
굴절률
170 ° (C=0.5, Dioxane)
인화점
>200℃
저장 조건
Refrigerator
용해도
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
산도 계수 (pKa)
12.36±0.60(Predicted)
수용성
115mg/L(25 ºC)
Merck
7722
BRN
2065301
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
53-03-2(CAS DataBase Reference)
NIST
Prednisone(53-03-2)
EPA
Prednisone (53-03-2)

안전

위험품 표기 Xn,C,F
위험 카페고리 넘버 63-34-11
안전지침서 36/37/39-45-26-16
유엔번호(UN No.) UN 1648 3 / PGII
WGK 독일 3
RTECS 번호 TU4154100
위험 등급 IRRITANT
HS 번호 29379000
유해 물질 데이터 53-03-2(Hazardous Substances Data)

프레드니손 C화학적 특성, 용도, 생산

화학적 성질

White or almost white, crystalline powder.

용도

Adrenocortical steroid. Glucocorticoid, antiinflammatory.

용도

Downregulates TNF-α production and NF-κB expression

정의

ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.

상표명

Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).

일반 설명

Odorless white crystalline powder.

일반 설명

Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.

공기와 물의 반응

Very slightly water soluble .

위험도

Questionable carcinogen.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.

Purification Methods

Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]

프레드니손 준비 용품 및 원자재

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