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(R)-CPP

(R)-CPP 구조식 이미지

카스 번호:: 126453-07-4

상품명:: (R)-CPP

동의어(영문):: D-CPP;(R)-CCP;(R)-CPP;CPP (R)-;(R)CPP,(R) CPP;rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid;(R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid;[3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid

CBNumber:: CB6725314

분자식:: C8H17N2O5P

포뮬러 무게:: 252.2

MOL 파일:: 126453-07-4.mol

속성

안전

용도

공급 업체 61

(R)-CPP 속성

끓는 점: 546.7±60.0 °C(Predicted)

밀도: 1.408±0.06 g/cm3(Predicted)

저장 조건: Desiccate at RT

용해도: Water: 100mM

물리적 상태: 백색 결정성 분말.

산도 계수 (pKa): 1.89±0.20(Predicted)

수용성: 물에 100mM까지 용해됨

안전

(R)-CPP C화학적 특성, 용도, 생산

개요

(R)-CPP is an NMDA receptor antagonist (K_i = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with K_i values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA₂ = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA₂ = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED₅₀ = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED₅₀ = 127 μmol/kg).

용도

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.

생물학적 활성

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).

(R)-CPP 준비 용품 및 원자재

원자재

117414-78-5 D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID

준비 용품

(R)-CPP 공급 업체

글로벌( 61)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

(R)-CPP 관련 검색:

클로린화된 폴리올레핀 2-Piperazinemethanol (R)-PIPERAZINE-2-CARBOXYLIC ACID PIPERAZINE-2-CARBOXYLIC ACID D-SS-(N-METHYLAMINO)ALANINE 3-(N,N-Dimethylamino)-D-alanine D-2,3-Diaminopropionic acid 3-Aminopropylphosphonic acid 3-(N,N-Diethylamino)-L-alanine (R)-CPP 4-CPP 4-METHYLPIPERAZINE-2-CARBOXYLIC ACID 2-Piperazinecarboxaldehyde Aminoacylproline Carboxypeptidase, CPP, Penicillocarboxypeptidase S-1, Proline Carboxypeptidase,CPP【NMDA receptor antagonist】 (R)-2-(2,4-Dichlorophenoxy)propanoic acid azaleucine [CPP1-7, NPY19-23, Ala31, Aib32, Gln34]-Pancreatic polypeptide (+/-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID