아스테미졸
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아스테미졸 속성
- 녹는점
- 172.9°C
- 끓는 점
- 627.3±65.0 °C(Predicted)
- 밀도
- 1.1587 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >20mg/mL
- 산도 계수 (pKa)
- pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)
- 물리적 상태
- 가루
- 색상
- 크리스탈
- 수용성
- DMSO(25mg/ml), 에탄올(25mg/ml), 클로로포름, 메탄올 및 물(부분적으로 혼화 가능)에 용해됩니다.
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| 유엔번호(UN No.) | UN 2811 6.1 / PGII | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | DD8968000 | ||
| HS 번호 | 2933992600 | ||
| 유해 물질 데이터 | 68844-77-9(Hazardous Substances Data) | ||
| 독성 | LD50 orl-rat: >2560 mg/kg AIPTAK 251,39,81 | ||
| 기존화학 물질 | KE-17044 |
아스테미졸 C화학적 특성, 용도, 생산
개요
Astemizole belongs to the second-generation class of non-sedating, non-anticholinergic antihistamines. Its non-sedating properties appear to result from its poor penetration of the blood brain barrier. As a result it shows no potentiation of CNS depressants, including alcohol. Its long half-life allows once-daily dosing.화학적 성질
Crystalline Solid용도
Astemizole is used for preventing and treating severe seasonal and chronic allergic rhinitis, allergic conjunctivitis, hives, Quinke’s edema, other allergic conditions and dermatitis. Synonyms of this drug are hismanal, histazol, and others.정의
ChEBI: A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.World Health Organization (WHO)
The first clinically interesting histamine ti-antagonists were introduced in the late forties and early fifties. Several histamine ti-antagonists have a similar cardiac effect to that seen with astemizole and terfenadine. Serious cardiovascular adverse reactions have been reported when used concomitantly with imidazole antifungals and macrolide antibiotics.생물학적 활성
Orally active, potent histamine H 1 antagonist (IC 50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC 50 = 227 - 734 nM). Also potent hERG K + channel blocker (IC 50 = 0.9 nM) that displays cardiotoxicity in vivo .Safety Profile
Poison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Humansystemic effects by ingestion: arrhythmias, coma, nauseaor vomiting, somnolence. When heated to decompositionit emits toxic fumes of F?? and NOx.아스테미졸 준비 용품 및 원자재
원자재
준비 용품
아스테미졸 공급 업체
글로벌( 173)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 3632 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9358 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Shanghai kingmorn biotechnology Co.,Ltd. | 021-62200788 15000569291 |
2199306478@qq.com | CHINA | 100 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
아스테미졸 관련 검색:
벤젠 아스테미졸
Cisapride
1-BENZYL-1H-BENZOIMIDAZOL-2-YLAMINE
2-AMINO-1-METHYLBENZIMIDAZOLE
norastemizole
2-(AMINOMETHYL)-1-METHYLIMIDAZOLE
1-ETHYL-1H-BENZOIMIDAZOL-2-YLAMINE
1-PHENETHYL-PIPERIDIN-4-YLAMINE
4-AMINO-1-(1-PROPYL)-PIPERIDINE
1-(4-METHOXYPHENETHYL)-4-AMINOPIPERIDINE
1-BENZYL-1H-IMIDAZOL-2-YLAMINE
O-Desmethyl Astemizole
2-AMINO-1-((4-FLUOROPHENYL)METHYL)BENZI&
ASTEMIZOLE, [METHYL-3H]-
DESMETHYL ASTEMIZOLE
astemizole tetrachlorocuprate(II)
DESMETHYL ASTEMIZOLE HYDROCHLORIDE