G-STROPHANTHIN

G-STROPHANTHIN 속성

G-STROPHANTHIN C화학적 특성, 용도, 생산

개요

One of several cardiac glycosides that have been used clinically as cardiotonic agents and diuretics. Ouabain is obtained from the seeds of Strophanthus gratus, Acokanthera ouabaio, and related species. It was formerly prescribed under the name strophanthuis as the purified seed extract.

화학적 성질

Ouabain is a white crystalline solid.

일반 설명

Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.

반응 프로필

When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].

건강위험

G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.

화재위험

When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)

생물학적 활성

Selective Na + , K + -ATPase inhibitor.

Safety Profile

Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes

잠재적 노출

Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.

운송 방법

UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]

비 호환성

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

G-STROPHANTHIN 준비 용품 및 원자재

원자재

준비 용품

G-STROPHANTHIN 공급 업체

공급자	전화	이메일	국가	제품 수	이점
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70

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