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5-Bromo-7-azaindole

5-Bromo-7-azaindole 구조식 이미지

카스 번호:: 183208-35-7

상품명:: 5-Bromo-7-azaindole

동의어(영문):: 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-7H-pyrrolo[2,3-b]pyridine;SW-57;SWF-57;SKL277;EOS-60661;5-BROMO AZAINDOLE;5-bromo-7-azindole;5-BROMO-7-AZAINDOLE;5-Bromo-7-azaindole,96%

CBNumber:: CB6756981

분자식:: C7H5BrN2

포뮬러 무게:: 197.03

MOL 파일:: 183208-35-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 585

5-Bromo-7-azaindole 속성

녹는점: 176-180 °C

끓는 점: 357.4±42.0 °C(Predicted)

밀도: 1.79±0.1 g/cm3(Predicted)

저장 조건: Sealed in dry,Room Temperature

산도 계수 (pKa): 6.25±0.20(Predicted)

물리적 상태: 결정성 분말

색상: 흰색에서 노란색으로

InChIKey: LPTVWZSQAIDCEB-UHFFFAOYSA-N

LogP: 1.8 at 25℃ and pH7

CAS 데이터베이스: 183208-35-7(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi,Xn
위험 카페고리 넘버	22-41
안전지침서	26-39
WGK 독일	3
위험 등급	IRRITANT
HS 번호	29339900

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501
H318	눈에 심한 손상을 일으킴	심한 눈 손상 또는 자극성 물질	구분 1	위험		P280, P305+P351+P338, P310

예방조치문구:

P280

보호장갑/보호의/보안경/안면보호구를 착용하시오.

NFPA 704

	1
2		0

5-Bromo-7-azaindole C화학적 특성, 용도, 생산

화학적 성질

White to light brown powder or crystal

Synthesis

In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20 mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml), 40 ℃ stirring for 2 hours, the reaction is completed, to remove the ethanol, add 50 ml of water residue is completely dissolved, saturated NaHCO3 solution and to pH=8, and filtering the resulting solid, after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g, 60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of the reaction, rotary evaporated to remove chloroform, adding 50 ml saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined organic phase with water (50 ml) for washing and then the saturated salt water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b] pyridine the crude product, the crude product is chloroform: hexane=2:1 (volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield 77.6%, melting point:176.8-177.3 ℃.

Solubility in organics

The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.

5-Bromo-7-azaindole 준비 용품 및 원자재

원자재

아연 7-Azaindole tert-부틸알코올 삼불화붕소화합물 브롬 아세트산(빙초산) Manganese triacetate dihydrate 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]- Acetamide, N-[5-bromo-3-[2-(trimethylsilyl)ethynyl]-2-pyridinyl]- 5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE 3,3,5-Tribromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 2-Aminopyrrole 5-bromo-3-ethynylpyridin-2-amine Methyl 5-bromo-7-azaindole-3-carboxylate 5-BROMO-3-((TRIMETHYLSILYL)ETHYNYL)PYRIDIN-2-AMINE 5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o

준비 용품

1-PropanesulfonaMide, N-[3-[[5-broMo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

5-Bromo-7-azaindole 공급 업체

글로벌( 585)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Shanghai Jinli Pharmaceutical Co.,Ltd	+86-21-57256005 +86-15921811235	chang@shjlchem.com	China	20	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

5-Bromo-7-azaindole 관련 검색:

3-인돌부틸산 인돌-3-아세트산 피리딘 폴리비닐피로리돈 피롤리딘 N-메틸-2-피롤리디논 인드메타신 2-피로리딘온,1-에테닐- 브롬 1-(2,6-Dichlorophenyl)indolin-2-one 7-Azaindole 5-BROMO-1H-PYRROLO[2,3-C]PYRIDIN-2(3H)-ONE tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride No Chinese name rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE 1-METHYL-5-NITRO-1H-INDAZOLE