3-Amino-5-fluoropyridine
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3-Amino-5-fluoropyridine 속성
- 녹는점
- 86°C
- 끓는 점
- 232.7±20.0 °C(Predicted)
- 밀도
- 1.257±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 3.74±0.20(Predicted)
- 색상
- Light orange to Yellow to Green
- CAS 데이터베이스
- 210169-05-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-36/37/38-22 | ||
| 안전지침서 | 26-36-36/37 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 2933399990 |
3-Amino-5-fluoropyridine C화학적 특성, 용도, 생산
화학적 성질
Light yellow Crystal용도
3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults.제조 방법
synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29.
주요 응용
Reactant for:Preparation of nonpeptide inhibitors of measles virus entry.
3-Amino-5-fluoropyridine 준비 용품 및 원자재
원자재
N-메틸모폴린
노르말헥산
아질산 아이소아밀
에틸알코올
포름산암모늄
디페닐포스포릴아지드
벤질 알코올
5-Fluoronicotinic acid
팔라듐
붕불화수소산
디에틸에테르
1,2-디클로로에탄
5-Methylpyridin-3-amine
염산
메틸알콜
Carbamic acid, N-(5-fluoro-3-pyridinyl)-, phenylmethyl ester
2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE
2,4,6-TRIBROMO-3,5-DIFLUOROPYRIDINE
준비 용품
3-Amino-5-fluoropyridine 공급 업체
글로벌( 316)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 811 | 58 |
| Dongfan Chem. Co., Ltd. | 021-34500607 13391355195 |
sales@dfanchem.com | CHINA | 61 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
3-Amino-5-fluoropyridine 관련 검색:
5-Fluoro-2-oxindole
4-BROMO-5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
2-BROMO-5-FLUORO-3-NITROPYRIDINE
2-AMINO-3-NITRO-5-FLUOROPYRIDINE
3-FLUORO-4-NITROPYRIDINE-N-OXIDE
2-CHLORO-5-FLUORO-3-NITROPYRIDINE
3-Fluoro-4-nitropyridine
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
3-Amino-5-fluoropyridine
2-CHLORO-3-FLUORO-4-NITROPYRIDINE N-OXIDE
4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE
5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE
4-Amino-2-fluoropyridine97%,4-AMINO-2-FLUOROPYRIDINE
2-Amino-5-fluoropyridine
6-FLUORO-3,4-PYRIDINEDIAMINE
2-Amino-3-fluoropyridine97%,2-AMINO-3-FLUOROPYRIDINE 98%,2-AMINO-3-FLUOROPYRIDINE
BOC-5-AMINO-2-FLUOROPYRIDINE,N-Boc-5-amino-2-fluoropyridine