Adapalene

Adapalene 구조식 이미지
카스 번호:
106685-40-9
상품명:
Adapalene
동의어(영문):
Adapalen;Differin;6-(3-(AdaMantan-1-yl)-4-Methoxyphenyl)-2-naphthoic acid;6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHALENE CARBOXYLIC ACID;6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid;ADPL;CD-271;Differi;p75(NTR);ADAPALENE
CBNumber:
CB6771245
분자식:
C28H28O3
포뮬러 무게:
412.52
MOL 파일:
106685-40-9.mol
MSDS 파일:
SDS

Adapalene 속성

녹는점
319-3220C
끓는 점
606.3±55.0 °C(Predicted)
밀도
1.233±0.06 g/cm3(Predicted)
RTECS 번호
QJ1987000
저장 조건
2-8°C
용해도
DMSO: >10mg/mL
산도 계수 (pKa)
4.2(at 25℃)
물리적 상태
흰색 고체
색상
흰색에서 황백색까지
Merck
14,150
안정성
제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 DMF 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
InChIKey
LZCDAPDGXCYOEH-UHFFFAOYSA-N
SMILES
C1=C2C(C=C(C3=CC=C(OC)C(C45CC6CC(CC(C6)C4)C5)=C3)C=C2)=CC=C1C(O)=O
CAS 데이터베이스
106685-40-9(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
WGK 독일 nwg
HS 번호 2918992090
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2 0

Adapalene MSDS


6-[3-(1-Adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid

Adapalene C화학적 특성, 용도, 생산

개요

Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively). It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs). It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants. It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema. Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner. Formulations containing adapalene have been used in the treatment of acne vulgaris.

화학적 성질

White Crystalline Solid

용도

Adapalene has been used as a retinoic acid receptor (RAR) agonist to study its effects on inhibiting transcription of hepatitis B virus in covalently closed circular DNA (cccDNA). It has also been used as a component to culture mixed lymphocyte reactions (MLR) to study its effects on isolated macrophages.

Indications

Adapalene (Differin) is a polyaromatic retinoidlike compound that binds to specific retinoic acid nuclear receptors and is thought to normalize the differentiation of keratinocytes in the sebaceous acroinfundibulum. Adapelene is indicated for topical treatment of acne. Minor local irritation is a common, usually tolerable side effect. In contrast to other drugs of the retinoid group, adapalene has not been shown to be teratogenic in rodents. However, since adequate human studies are lacking, its use in pregnant women should be discouraged until further information is available.

정의

ChEBI: A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.

일반 설명

Adapalene is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.

생물학적 활성

Retinoic acid analog that is a RAR β and RAR γ agonist (AC 50 values are 2.2, 9.3, 22 and > 1000 nM for RAR β , RAR γ , RAR α and RXR α receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro . Displays comedolytic activity.

Adapalene 준비 용품 및 원자재

원자재

준비 용품


Adapalene 공급 업체

글로벌( 673)공급 업체
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Sigma Audley
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Beijing Cooperate Pharmaceutical Co.,Ltd
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ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29919 58

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