ChemicalBook
Chinese English Japanese Germany Korea

테트라하이드로푸란

테트라하이드로푸란
테트라하이드로푸란 구조식 이미지
카스 번호:
109-99-9
한글명:
테트라하이드로푸란
동의어(한글):
테트라히드로푸란;부탄,알파,델타-산화물;시클로테트라메틸렌산화물;옥사시클로펜탄;테트라메틸렌산화물;테트라하이드로푸란;테트라하이드로퓨란;테트라하이드로퓨란250ppmBHT;티에치에프;테트라하이드로푸란(THF)
상품명:
Tetrahydrofuran
동의어(영문):
THF;xxxx;PTHF;oxolan;5C-APB;Oxolane;PTMEG 250;NCI-C60560;Hydrofuran;Furanidine
CBNumber:
CB6852795
분자식:
C4H8O
포뮬러 무게:
72.11
MOL 파일:
109-99-9.mol

테트라하이드로푸란 속성

녹는점
-108°C
끓는 점
66 °C
밀도
0.887 g/mL at 20 °C
증기 밀도
2.5 (vs air)
증기압
<0.01 mm Hg ( 25 °C)
굴절률
n20/D 1.465
인화점
>230 °F
저장 조건
2-8°C
용해도
water: soluble
물리적 상태
Liquid
색상
<10(APHA)
상대극성
0.207
수소이온지수(pH)
7-8 (200g/l, H2O, 20℃)
냄새
Ethereal, detectable at 2 to 50 ppm
폭발한계
1.5-12.4%(V)
수용성
miscible
어는점
-108℃
감도
Air Sensitive & Hygroscopic
최대 파장(λmax)
λ: 245 nm Amax: ≤0.26
λ: 275 nm Amax: ≤0.046
λ: 315 μm Amax: ≤0.0044
Merck
14,9211
BRN
102391
노출 한도
TLV-TWA 200 ppm (590 mg/m3) (ACGIH, MSHA, and OSHA); STEL 250 ppm (ACGIH); IDLH 20,000 ppm (NIOSH).
안정성
Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s
InChIKey
WYURNTSHIVDZCO-UHFFFAOYSA-N
CAS 데이터베이스
109-99-9(CAS DataBase Reference)
NIST
Furan, tetrahydro-(109-99-9)
EPA
Furan, tetrahydro-(109-99-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,F,Xn
위험 카페고리 넘버 36/37/38-36/37-19-11-40
안전지침서 26-36-33-29-16-46-37-13
유엔번호(UN No.) UN 2924 3/PG 2
WGK 독일 1
RTECS 번호 MD0916000
F 고인화성물질 3-10-23
자연 발화 온도 610 °F
TSCA Yes
위험 등급 3
포장분류 II
HS 번호 29321100
유해 물질 데이터 109-99-9(Hazardous Substances Data)
독성 LD50 oral (rat) 2880 mg/kg
LC50 inhal (rat) 21,000 ppm (3 h)
PEL (OSHA) 200 ppm (590 mg/m3)
TLV-TWA (ACGIH) 200 ppm (590 mg/m3)
STEL (ACGIH) 250 ppm (737 mg/m3)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H333 흡입하면 유해할 수 있음 급성 독성 물질 흡입 구분 5 P304+P312
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P405 밀봉하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.

테트라하이드로푸란 MSDS


1,4-Epoxybutane

테트라하이드로푸란 C화학적 특성, 용도, 생산

용도

고분자 용제, 특히 폴리 염화 비닐. 그리 냐드 및 금속 수 소화물 반응을위한 반응 매질로서. 부티로 락톤, 숙신산, 1,4- 부탄디올 디 아세테이트의 합성. 조직학 기법의 용매.

용도

테트라 하이드로 푸란 (THF)은 고분자, 특히 폴리 비닐 클로라이드 용 산업용 용매입니다. 그리 냐드 및 금속 수 소화물 반응을위한 반응 매질로서. 부티로 락톤, 숙신산, 1,4- 부탄디올 디 아세테이트의 합성. 조직학 기법의 용매. 그것은 자성 테이프 및 합성 피혁과 같은 코팅 매체에 사용되는 미 경화 및 열가소성 폴리 우레탄의 수지 용매로 사용됩니다. 셀로판 코팅 및 플라스틱 용 인쇄 잉크 외에도 PVC 탑 코팅, 반응기 세척 및 필름 주조에도 사용됩니다.

용도

테트라 하이드로 푸란 (THF)은 또한 접착제, 비닐 필름 및 셀로판, 산업용 수지, 엘라스토머, 코팅 및 인쇄 잉크와 같은 분야에서 다양한 용도로 사용되는 다용도 솔벤트입니다. THF의 구체적인 용도는 PVC 시멘트의 배합입니다. THF 용제 시멘트는 경화 시간을 조절하기 위해 추가 용제 및 무기 충전제로 제형화할 수 있습니다. THF는 조인트 형성 전에 PVC 형 클리너로도 기능 할 수 있습니다. 테트라 하이드로 푸란 (THF)은 세정제, 페인트 제거제 및 스트립 핑 유체, 기능성 유체, 래커 및 코팅제, 접착제 및 기능성 유체 및 부식 방지제의 구성 요소로서 소비자 제품에 사용됩니다. 또한 이러한 목적을 위해 전문적으로 사용됩니다.

개요

Tetrahydrofuran (THF) is a chemical intermediate used in the manufacture of polymers as well as agricultural, pharmaceutical, and commodity chemicals. Manufacturing activities commonly occur in closed systems or under engineering controls that limit worker exposure and release to the environment. THF is also used as a solvent (e.g., pipe fitting) that may result in more significant exposures when used in confined spaces without sufficient ventilation. Although THF is naturally present in coffee aroma, floured chickpeas, and cooked chicken, natural exposures are not anticipated to pose a significant hazard.

화학적 성질

Tetrahydrofuran is a clear, colourless liquid with ether-like odour. It is highly flammable. Contact of tetrahydrofuran with strong oxidising agents may cause explosions. Tetrahydrofuran may polymerise in the presence of cationic initiators. Contact with lithium–aluminium hydride, with other lithium–aluminium alloys, or with sodium or potassium hydroxide can be hazardous.

화학적 성질

Tetrahydrofuran (THF, tetramethylene oxide, diethylene oxide, 1,4-epoxybutane, tetrahydrofurane, oxolane) is an industrial solvent widely recognized for its unique combination of useful properties. DuPont THF is better than 99.9% pure with a small (0.025-0.040 wt % ) amount of butylated hydroxytoluene (BHT, 4-methyl-2,6-di-tertbutyl phenol) added as an antioxidant. Tetrahydrofuran is a cycloaliphatic ether and is not "photochemically reactive" as defined in Section k of Los Angeles County's Rule 66 (equivalent to Rule 442 of the Southern California Air Pollution Control District). THF has an ethereal odor. The Odor Threshold is listed @ 3.8 (3M), 20-50 ppm, and 31 ppm.

용도

Suitable for HPLC, spectrophotometry, environmental testing

용도

Solvent for high polymers, especially polyvinyl chloride. As reaction medium for Grignard and metal hydride reactions. In the synthesis of butyrolactone, succinic acid, 1,4-butanediol diacetate. Solvent in histological techniques. May be used under Federal Food, Drug & Cosmetic Act for fabrication of articles for packaging, transporting, or storing of foods if residual amount does not exceed 1.5% of the film: Fed. Regist. 27, 3919 (Apr. 25, 1962).

용도

Tetrahydrofuran is used primarily (80%) to make polytetramethylene ether glycol, the base polymer used primarily in the manufacture of elastomeric fibers (e.g., spandex) as well as polyurethane and polyester elastomers (e.g., artificial leather, skateboard wheels). The remainder (20%) is used in solvent applications (e.g., pipe cements, adhesives, printing inks, and magnetic tape) and as a reaction solvent in chemical and pharmaceutical syntheses.

용도

Butylene oxide is used as a fumigant and inadmixture with other compounds. It is usedto stabilize fuel with respect to color andsludge formation.

용도

Tetrahydrofuran is used as a solvent forresins, vinyls, and high polymers; as a Grignardreaction medium for organometallic,and metal hydride reactions; and in the synthesisof succinic acid and butyrolactone.

정의

A colorless liquid widely used as a solvent and for making polymers.

정의

ChEBI: A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.

일반 설명

A clear colorless liquid with an ethereal odor. Less dense than water. Flash point 6°F. Vapors are heavier than air.

공기와 물의 반응

Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Soluble in water.

반응 프로필

Tetrahydrofuran reacts violently with oxidizing agents leading to fires and explosions [Handling Chemicals Safely 1980. p. 891]. Subject to peroxidation in the air. Peroxides or their products react exothermically with lithium aluminum hydride [MCA Guide for Safety 1973]. Thus, use as a solvent for lithium aluminum hydride has led to fires. Using potassium hydroxide or sodium hydroxide to dry impure Tetrahydrofuran that contains peroxides has resulted in explosions. A violent explosion occurred during the preparation of sodium aluminum hydride from sodium and aluminum in a medium of Tetrahydrofuran [Chem. Eng. News 39(40):57. 1961]. THF forms explosive products with 2-aminophenol [Lewis 3227].

건강위험

Vapors cause nausea, dizziness, headache, and anesthesia. Liquid can de-fat the skin and cause irritation. Liquid also irritates eyes.

건강위험

The toxicity of tetrahydrofuran is of loworder in animals and humans. The targetorgans are primarily the respiratory systemand central nervous system. It is an irritantto the upper respiratory tract and eyes.At high concentrations it exhibits anestheticproperties similar to those of many loweraliphatic ethers. Exposure to concentrationsabove 25,000 ppm in air can cause anesthesiain humans. Other effects noted were strongrespiratory stimulation and fall in bloodpressure (ACGIH 1986). Kidney and liverinjuries occurred in experimental animalsexposed to 3000 ppm for 8 hours/day for20 days (Lehman and Flury 1943). Inhalationof high concentrations of vapors or ingestionof the liquid also causes nausea, vomiting,and severe headache. The acute oraltoxicity is low; the LD50 value in rats is in therange of 2800 mg/kg. The inhalation LC50value in rats is 21,000 ppm/3 h.

건강위험

The acute toxicity of THF by inhalation and ingestion is low. Liquid THF is a severe eye irritant and a mild skin irritant, but is not a skin sensitizer. At vapor levels of 100 to 200 ppm, THF irritates the eyes and upper respiratory tract. At high concentrations (25,000 ppm), THF vapor can produce anesthetic effects. Since the odor threshold for THF is well below the permissible exposure limit, this substance is regarded as having good warning properties.
Limited animal testing indicates that THF is not carcinogenic and shows developmental effects only at exposure levels producing other toxic effects in adult animals. Bacterial and mammalian cell culture studies demonstrate no mutagenic activity with THF.

화재위험

Flash Point (°F): 20 ℃; Flammable Limits in Air (%): 1.5-18.3; Fire Extinguishing Agents: Dry chemical, alcohol foam, carbon dioxide; Fire Extinguishing Agents Not To Be Used: Water may be ineffective; Special Hazards of Combustion Products: No data; Behavior in Fire: Containers may explode in fires. Apply water to cool containers from a safe distance; Ignition Temperature (°F): 959; Electrical Hazard: No data; Burning Rate: No data.

화재위험

THF is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." A 5% solution of THF in water is flammable. THF vapor forms explosive mixtures with air at concentrations of 2 to 12% (by volume). Carbon dioxide or dry chemical extinguishers should be used for THF fires.
THF can form shockand heat-sensitive peroxides, which may explode on concentration by distillation or evaporation. Always test samples of THF for the presence of peroxides before distilling or allowing to evaporate. THF should never be distilled to dryness.

인화성 및 폭발성

THF is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." A 5% solution of THF in water is flammable. THF vapor forms explosive mixtures with air at concentrations of 2 to 12% (by volume). Carbon dioxide or dry chemical extinguishers should be used for THF fires.
THF can form shock- and heat-sensitive peroxides, which may explode on concentration by distillation or evaporation. Always test samples of THF for the presence of peroxides before distilling or allowing to evaporate. THF should never be distilled to dryness.

화학 반응

Reactivity with Water No reaction; Reactivity with Common Materials: No data; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: May occur when the product is in contact with strong acids and bases; Inhibitor of Polymerization: No data.

공업 용도

Tetrahydrofuran (THF), the saturated derivative of furan, when used as a solvent for high molecular weight polyvinyl chloride (PVC), vinyl chloride copolymers, and polyvinylidene chloride copolymers at ambient temperatures yields solutions of high solids content. Blends of THF and methyl ethyl ketone are often used for increased solvency in certain polymer compositions. Applications for THF polymer solutions include PVC top coatings of automotive upholstery, audio tape coatings of polyurethane/metal oxides on polyester tape, polyurethane coatings for fabric finishes, water-vapor barrier film coatings of PVC, and polyvinylidene chloride copolymers onto cellophane film. Tetrahydrofuran is an excellent solvent for many inks used for printing on PVC film and on PVC plastic articles. Polyvinyl chloride pipe welding cements are made by dissolving the resin in THF solvent. Other adhesive applications include cements for leather, plastic sheeting, and for molded plastic assemblies. Other uses of THF are as a chemical intermediate and as a complexing solvent for various inorganic, organometallic, and organic compounds. These THF complexes are important as Grignard reagents, catalysts for organic reactions, and in stereo-specific polymerizations. Tetrahydrofuran is the solvent of choice in many pharmaceutical reactions and applications. The excellent solvency of THF makes this solvent ideal for solvent cleaning of polymer manufacturing and processing equipment.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by inhalation: general anesthesia. Mutation data reported. Irritant to eyes and mucous membranes. Narcotic in high concentrations. Reported as causing injury to liver and kidneys. Flammable liquid. A very dangerous fire hazard when exposed to heat, flames, oxidizers. Explosive in the form of vapor when exposed to heat or flame. In common with ethers, unstabilized tetrahydrofuran forms thermally explosive peroxides on exposure to air. Stored THF must always be tested for peroxide prior to distdlation. Peroxides can be removed by treatment with strong ferrous sulfate solution made slightly acidic with sodium bisulfate. Caustic alkalies deplete the inhibitor in THF and may subsequently cause an explosive reaction. Explosive reaction with KOH, NaAlH2, NaOH, sodium tetrahydroaluminate. Reacts with 2-aminophenol + potassium dioxide to form an explosive product. Reacts with lithium tetrahydroaluminate or borane to form explosive hydrogen gas. Violent reaction with metal halides (e.g., hafnium tetrachloride, titanium tetrachloride, zirconium tetrachloride). Vigorous reaction with bromine, calcium hydride + heat. Can react with oxidizing materials. To fight fire, use foam, dry chemical, COa. When heated to decomposition it emits acrid smoke and irritating fumes. See also 2TETRAHYDROFURYL HYDROPEROXIDE

잠재적 노출

The primary use of tetrahydrofuran is as a solvent to dissolve synthetic resins, particularly polyvinyl chloride and vinylidene chloride copolymers. It is also used to cast polyvinyl chloride films, to coat substrates with vinyl and vinylidene chloride; and to solubilize adhesives based on or containing polyvinyl chloride resins. A second large market for THF is as an electrolytic solvent in the Grignard reaction-based production of tetramethyl lead. THF is used as an intermediate in the production of polytetramethylene glycol.

응급 처치

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

저장

THF should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers. Containers of THF should be dated when opened and tested periodically for the presence of peroxides.

운송 방법

UN2056 Tetrahydrofuran, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

It is obtained commercially by catalytic hydrogenation of furan from pentosan-containing agricultural residues. It was purified by refluxing with, and distilling from LiAlH4 which removes water, peroxides, inhibitors and other impurities [Jaeger et al. J Am Chem Soc 101 717 1979]. Peroxides can also be removed by passage through a column of activated alumina, or by treatment with aqueous ferrous sulfate and sodium bisulfate, followed by solid KOH. In both cases, the solvent is then dried and fractionally distilled from sodium. Lithium wire or vigorously stirred molten potassium have also been used for this purpose. CaH2 has also been used as a drying agent. Several methods are available for obtaining the solvent almost anhydrous. Ware [J Am Chem Soc 83 1296 1961] dried it vigorously with sodium-potassium alloy until a characteristic blue colour was evident in the solvent at Dry-ice/cellosolve temperatures. The solvent is kept in contact with the alloy until distilled for use. Worsfold and Bywater [J Chem Soc 5234 1960], after refluxing and distilling from P2O5 and KOH, in turn, refluxed the solvent with sodium-potassium alloy and fluorenone until the green colour of the disodium salt of fluorenone was well established. [Alternatively, instead of fluorenone, benzophenone, which forms a blue ketyl, can be used.] The tetrahydrofuran was then fractionally distilled, degassed and stored above CaH2. p-Cresol or hydroquinone inhibit peroxide formation. The method described by Coetzee and Chang [Pure Appl Chem 57 633 1985] for 1,4-dioxane also applies here. Distillations should always be done in the presence of a reducing agent, e.g. FeSO4. [Beilstein 17 H 10, 17 I 5, 17 II 15, 17 III/IV 24, 17/1 V 27.] It irritates the skin, eyes and mucous membranes, and the vapour should never be inhaled. It is HIGHLY FLAMMABLE, and the necessary precautions should be taken. Rapid purification: Purification as for diethyl ether.

비 호환성

Forms thermally explosive peroxides in air on standing (in absence of inhibitors). Peroxides can be detonated by heating, friction, or impact. Reacts violently with strong oxidizers, strong bases and some metal halides. Attacks some forms of plastics, rubber and coatings.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Concentrated waste containing peroxides-perforation of a container of the waste from a safe distance followed by open burning.

테트라하이드로푸란 준비 용품 및 원자재

원자재

준비 용품


테트라하이드로푸란 공급 업체

글로벌( 394)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 274 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1750 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 176 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 sales@tjzxchem.com CHINA 558 58
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 488 55
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 928 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 407 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Aoxuan Biological Technology Co., Ltd.
17073140108
- CHINA 147 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55

테트라하이드로푸란 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved