2-Fluoroaniline is a clear colorless to brown liquid, toxic, insoluble in water, soluble in ethanol and ether, its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of fire and high heat. Reacts with oxidants. Decomposed by high heat to release toxic gases.
용도
2-Fluoroaniline (cas# 348-54-9) is a useful reagent for the synthesis of insecticides.
정의
ChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.
일반 설명
Clear liquid with a mild sweet odor. Sinks in and mixes slowly with water.
공기와 물의 반응
Water soluble.
반응 프로필
2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
건강위험
Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.
화재위험
Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires.
신진 대사 경로
2-Fluoro and 3-fluoroanilines are preferentially
hydroxylated at the para-position, and 4-fluoroaniline is
both p- and o-hydroxylated to a significant extent by
rat liver microsomes and is not accompanied with an
NIH shift to give 4-hydroxyl-3-fluoroaniline.
