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벤즈아마이드

벤즈아마이드
벤즈아마이드 구조식 이미지
카스 번호:
55-21-0
한글명:
벤즈아마이드
동의어(한글):
벤즈아마이드
상품명:
Benzamide
동의어(영문):
Benzamid;NSC 3114;ai3-01031;BENZAMIDE;Carbonamide;BENZOYLAMIDE;BENZOIC AMIDE;Benzamide,99%;Benzamide >BENZAMIDE 98+%
CBNumber:
CB6853808
분자식:
C7H7NO
포뮬러 무게:
121.14
MOL 파일:
55-21-0.mol

벤즈아마이드 속성

녹는점
125-128 °C(lit.)
끓는 점
228°C
밀도
1.341
증기압
0.000056 hPa (20 °C)
굴절률
1.5323 (estimate)
인화점
180°C
저장 조건
Store below +30°C.
용해도
ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to light yellow
산도 계수 (pKa)
13.0(at 25℃)
물리적 상태
Crystalline Powder
색상
White to almost white
수소이온지수(pH)
6.9 (H2O)(saturated solution)
pH 범위
6.9
수용성
1.35 g/100 mL (20 ºC)
Merck
14,1060
BRN
385876
안정성
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS 데이터베이스
55-21-0(CAS DataBase Reference)
NIST
Benzamide(55-21-0)
EPA
Benzamide (55-21-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-68
안전지침서 22-24/25-36/37
WGK 독일 1
RTECS 번호 CU8700000
자연 발화 온도 >500 °C
TSCA Yes
HS 번호 29242995
유해 물질 데이터 55-21-0(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 1125 mg/kg
기존화학 물질 KE-02140
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
1
2 0

벤즈아마이드 MSDS


Benzamide

벤즈아마이드 C화학적 특성, 용도, 생산

개요

Benzamide appears as off-white crystals or powder. It is combustible and incompatible with strong oxidising agents and strong bases. On combustion and thermal decomposition, it emits nitrogen oxides, carbon monoxide, and carbon dioxide.
Benzamide is a carbonic acid amide of benzoic acid. Benzamide exhibits an angle of about 15º with the plane of the amide group; this shows that benzamide molecule is not flat. The rotation of the amide group relative to the aromatic ring may result from the repulsion interaction between the hydrogen atoms of the amide group and those of the aromatic ring.

화학적 성질

Benzamide is a combustible, colorless to beige, off-white, crystalline solid; freezing/melting point=132-133° C. It is slightly soluble in water, and soluble in many organic solvents.
Benzamide
Benzamide was used to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It was used to develop a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.

용도

Organic synthesis.

제조 방법

Take a mixture of 5 ml concentrated ammonia and 5 ml water in a conical flask with a well-fitting cork. Add 2 ml (2.4 g.) benzoyl chloride, cork the flask and shake vigorously. Heat generates due to the reaction, hence hold the cork securely during shaking. After 15 min not even a trace of oily benzoyl chloride remains. Filter the fine flakes, wash with cold water and recrystallise from hot water: yield, 1-5 g. Colourless crystals of benzamide.
Preparation of benzamide from benzoyl chloride
Preparation of benzamide from benzoyl chloride

정의

ChEBI: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 39, p. 1152, 1991
The Journal of Organic Chemistry, 59, p. 4114, 1994 DOI: 10.1021/jo00094a021
Synthetic Communications, 20, p. 1445, 1990

일반 설명

White powder.

공기와 물의 반응

Insoluble in water.

반응 프로필

Benzamide reacts with azo and diazo compounds to generate toxic gases. Forms flammable gases with strong reducing agents. Mixing with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. Combustion generates toxic mixed oxides of nitrogen (NOx).

위험도

Depresses the central nervous system; toxic.

화재위험

Flash point data for Benzamide are not available, however Benzamide is probably combustible.

Clinical Use

Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.

잠재적 노출

Benzamide is used in organic synthesis.

Purification Methods

Crystallise it from hot water (about 5mL/g), EtOH or 1,2-dichloroethane, and dry it in air. It has also been crystallised from dilute aqueous NH3, H2O, Me2CO, then *C6H6 using a Soxhlet extractor. Dry it in an oven at 110o for 8hours and store in a desiccator over 99% H2SO4. [Bates & Hobbs J Am Chem Soc 73 2151 1951, Beilstein 9 IV 725.]

벤즈아마이드 준비 용품 및 원자재

원자재

준비 용품


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