8-Aminoquinoline
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8-Aminoquinoline 속성
- 녹는점
- 60-65 °C (lit.)
- 끓는 점
- 174 °C/26 mmHg (lit.)
- 밀도
- 1.1148 (estimate)
- 굴절률
- 1.7080 (estimate)
- 인화점
- 174°C/26mm
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- pK1: 3.99(+1) (20°C,μ=0.01)
- 색상
- 녹색에서 베이지색 갈색
- 수용성
- 약간 용해됨
- 감도
- Air Sensitive
- BRN
- 114474
- CAS 데이터베이스
- 578-66-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 68-36/37/38-20/21/22-36/38 | ||
안전지침서 | 36/37/39-26-22-36 | ||
유엔번호(UN No.) | UN2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | VA9627000 | ||
위험 참고 사항 | Harmful/Irritant/Air Sensitive | ||
TSCA | Yes | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29334990 | ||
독성 | mmo-sat 50 mg/plate MUREAV 39,285,77 |
8-Aminoquinoline C화학적 특성, 용도, 생산
화학적 성질
green to beige-brown crystalline powder용도
8-Aminoquinoline is used as pesticide and pharmaceutical intermediate. It has been used in the preparation of base-stabilized terminal borylene complex of osmium. It is also used in the spectrophotometric determination of bivalent palladium.제조 방법
Synthesis of 8-aminoquinoline: Under an ice bath, sulfuric acid (2.0 mL) was added onto quinoline (5 mmol, 1.0 equiv) then 65% nitric acid (3.0 equiv) were added dropwise and stirred for 4h at rt. The mixture was poured into the ice water and neutralized with NaOH; and then extracted with dichloromethane. After dried over Na2SO4 and evaporated in vacuo, used next step without purification.Mixture of nitroquinolines and 5% Pd/C was solved in ethanol and suspension was saturated with hydrogen gas under atmospheric pressure at 40°C until the starting material was consumed. 2 h later, the mixture was filtered and evaporated. The crude product was purified by silica gel column chromatography, eluting with EtOAc in hexanes to yield the desired 8-aminoquinoline is isolated as a brown solid in a yield of 32%.
Obtained as a brown solid (231 mg, 32%); 1H NMR (500 MHz, CDCl3) δ 8.71 – 8.60 (m, 1H), 7.93 (d, J = 8.2 Hz, 1H), 7.29 – 7.16 (m, 2H), 7.02 (d, J = 8.1 Hz, 1H), 6.80 (d, J = 7.4 Hz, 1H), 4.89 (s, 2H).
일반 설명
8-Aminoquinoline fluoresce moderately to weakly in low dielectric media but not in strongly hydrogen-bonding or acidic aqueous media. The reaction of 8-aminoquinoline with chromium (III), manganese (II), iron (II) and (III), cobalt (II), nickel (II), copper (II), zinc (II), cadmium (II) and platinum (II) salts has been studied.Safety Profile
Human mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.Purification Methods
8-Aminoquinoline crystallises from EtOH, ligroin, octane or H2O, and complexes with metals. [Beilstein 22 III/IV 4708, 22/10 V 316.]8-Aminoquinoline 준비 용품 및 원자재
원자재
준비 용품
8-Aminoquinoline 공급 업체
글로벌( 399)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 |
angelia@hbmojin.com | China | 1098 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9287 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10311 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2966 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
8-Aminoquinoline 관련 검색:
3,7-디클로로-8-퀴놀린카복실산 8-하이드록시퀴놀린 에톡시퀸 이소퀴놀린 퀸하이드론 퀴놀린 카르보스티릴 124
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4-(Trifluoromethyl)quinolin-2-amine
6-AMINOQUINOLINE-4-CARBOXYLIC ACID
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6-Aminoquinoline
4-Aminoguinoline
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2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE
4-Aminomethylquinoline hydrochloride