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클로로탄산 메틸에스테르

클로로탄산 메틸에스테르
클로로탄산 메틸에스테르 구조식 이미지
카스 번호:
클로로탄산 메틸에스테르
Methyl chloroformate
MCF;tl438;TL 438;k-stoff;Metilcloroformiato;Methyl Chloroforate;rcrawastenumberu156;METHYL CHLOROFORMATE;Methylchloorformiaat;Methylechloroformate
포뮬러 무게:
MOL 파일:

클로로탄산 메틸에스테르 속성

끓는 점
70-72 °C(lit.)
1.223 g/mL at 25 °C(lit.)
증기 밀도
3.26 (vs air)
4.8 psi ( 20 °C)
n20/D 1.387(lit.)
64 °F
저장 조건
Store at 0-5°C
물리적 상태
Clear colorless to light yellow
CAS 데이터베이스
79-22-1(CAS DataBase Reference)
Carbonochloridic acid, methyl ester(79-22-1)
Carbonochloridic acid, methyl ester(79-22-1)


위험품 표기 F,T+
위험 카페고리 넘버 11-21/22-26-34
안전지침서 14-26-28-36/37/39-45-63-46-28A-39-36/37
유엔번호(UN No.) UN 1238 6.1/PG 1
WGK 독일 2
RTECS 번호 FG3675000
F 고인화성물질 10-19-21
위험 등급 6.1(a)
포장분류 I
HS 번호 29151300
유해 물질 데이터 79-22-1(Hazardous Substances Data)

클로로탄산 메틸에스테르 C화학적 특성, 용도, 생산

화학적 성질

Colorless liquid. Decomposed by hot water; stable to cold water. Soluble in methanol alcohol, ether, and benzene.

화학적 성질

Methyl chloroformate is a colorless liquid with an unpleasant, acrid odor. This is a highly corrosive and flammable material.


Chloroformic Acid Methyl Ester is used in the synthesis of a new class of potent Cdk4 inhibitors in the treatment of cancer. Also used in the synthesis of Phorboxazole B.

일반 설명

A colorless liquid with a pungent odor. Flash point 54°F. Corrosive to metals and tissue. Vapors heavier than air. Very toxic by inhalation. Used to make other chemicals and insecticides.

공기와 물의 반응

Highly flammable. Gives off hydrochloric acid fumes in contact with moist air. Slightly soluble in water and decomposed by water to hydrochloric acid with evolution of heat.

반응 프로필

Methyl chloroformate is incompatible with water, strong oxidizing agents, alcohols, bases (including amines). Decomposes slowly in water to yield methanol, HCl, and CO2; reaction can be hazardous if water is hot. Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].


Flammable, dangerous fire risk. Highly corrosive and irritant to skin and eyes.


Methyl chloroformate is highly toxic upon inhalation and upon ingestion. A concentration of 1 mg/liter (190 ppm) has been lethal in 10 minutes. It is corrosive and irritating to skin.


Methyl chloroformate is very dangerous when exposed to heat sources, sparks, flame, or oxidizers. Methyl chloroformate will react with water or steam to produce toxic and corrosive fumes. Vapors may travel to a source of ignition and flash back. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Toxic fumes of phosgene are produced when the material is heated to decomposition. Heat or steam should be avoided.


Flash Point (°F): 76 ℃; 73 ℃; Flammable Limits in Air (%): LEL = 6.7; Fire Extinguishing Agents: Water, dry chemical, foam, carbon dioxide; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride and phosgene may be formed; Behavior in Fire: Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back; Ignition Temperature : Data not available; Electrical Hazard: Data not available; Burning Rate: 2.0 mm/min.

화학 반응

Reactivity with Water: Reacts slowly, evolving hydrogen chloride (hydrochloric acid). Reaction can be hazardous if water is hot; Reactivity with Common Materials: Corrodes rubber; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by ingestion, inhalation, and intraperitoneal routes. Moderately toxic by skin contact. Human systemic effects by inhalation: conjunctiva irritation and respiratory effects. Corrosive to skin, eyes, and mucous membranes. Very dangerous fire hazard when exposed to heat sources, sparks, flame, or oxidzers. Reacts with water or steam to produce toxic and corrosive fumes. When heated to decomposition it emits toxic fumes of Cl-, methyl chloroformate, and phosgene.

잠재적 노출

Used in synthesis of pharmaceuticals; herbicides, plastics and other organic chemicals; as a solvent in the photographic industry; as a chemical intermediate in the production of other chemicals. In WWI it was used as military tear-producing warfare agent.

응급 처치

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 30 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water or milk. Do not induce vomiting. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

운송 방법

UN1238 Methyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material Inhalation Hazard Zone A

비 호환성

May form explosive mixture with air. Violent reaction with alkali metals; ethers. Incompatible with strong acids; strong bases; alcohols, oxidizers, dimethylsulfoxide; dimethyl formamide. Contact with water or moisture produces corrosive and poisonous hydrogen chloride gas, methanol and carbon monoxide. Corrodes metals in the presence of moisture. Attacks some plastics, rubber and coatings.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal

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