헥사클로로부타디엔
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헥사클로로부타디엔 속성
- 녹는점
- -19 °C
- 끓는 점
- 210-220 °C(lit.)
- 밀도
- 1.68
- 증기압
- 0.2 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.555(lit.)
- 인화점
- 210-220°C
- 저장 조건
- +4°C
- 용해도
- 에탄올과 에테르에 용해됨(US EPA, 1985)
- 물리적 상태
- 액체, 투명
- 냄새
- 희미한 테레빈유 냄새
- 수용성
- (mg/L):
4.78 at 25 °C (shake flask-LSC, Banerjee et al., 1980)
4 at 20–25 °C (Geyer et al., 1980)
- Merck
- 14,4678
- BRN
- 1766570
- Henry's Law Constant
- 3.55, 5.87, 6.90, 10.5, and 15.3 at 2.0, 6.0, 10.0, 18.0, and 25.0 °C, respectively (EPICS-SPME, Dewulf et al., 1999)
- 노출 한도
- Potential occupational carcinogen. NIOSH REL: TWA 20 ppb (240 mg/m3); ACGIH TLV: TWA 0.02 ppm (adopted).
- Dielectric constant
- 2.6（Ambient）
- 안정성
- 안정적인. 고무, 산화제와 호환되지 않습니다.
- CAS 데이터베이스
- 87-68-3(CAS DataBase Reference)
- IARC
- 3 (Vol. 73) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,N,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 24/25-34-40-50/53-39/23/24/25-23/24/25-11 | ||
| 안전지침서 | 26-36/37/39-45-61-60-36/37-16-7 | ||
| 유엔번호(UN No.) | UN 2279 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | EJ0700000 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| HS 번호 | 29032990 | ||
| 유해 물질 데이터 | 87-68-3(Hazardous Substances Data) | ||
| 독성 | LD50 in male, female mice, rats (mg/kg): 105, 76, 216, 175 i.p.; 80, 65, 250, 270 orally (Gradiski) | ||
| 기존화학 물질 | KE-05-0685 | ||
| 중점관리물질 필터링 | 별표2-23 |
헥사클로로부타디엔 C화학적 특성, 용도, 생산
개요
Hexachlorobutadiene was first synthesized in 1877 by chlorination of hexyl iodide. It is an industrial by-product of tetrachloroethylene, trichloroethylene, and perchloroethylene production.화학적 성질
colourless liquid (typical odour recognition threshold:물리적 성질
Clear, yellowish-green liquid with a mild to pungent, turpentine-like odor. Odor threshold concentration is 6 ppb (quoted, Keith and Walters, 1992).용도
Hexachloro-1,3-butadiene is used as an urinary biomarker as a tool for early screening of potential kidney toxicity. Hexachloro-1,3-butadiene (HCBD) causes kidney injury.일반 설명
A colorless liquid with a mild odor. Insoluble in water and denser than water. Nonflammable. May be toxic by ingestion or inhalation. Used as a solvent and heat transfer fluid.공기와 물의 반응
Insoluble in water.반응 프로필
Hexachloro-1,3-butadiene rapidly decomposes rubber on contact. Can react vigorously with oxidizing materials. Reacts to form an explosive product with bromine perchlorate. . Gives highly toxic and irritating chloride fumes when burned.위험도
Toxic by ingestion and inhalation, a questionable carcinogen.건강위험
Poisonous; may be fatal if inhaled, swallowed or absorbed through the skin. Inhalation causes repiratory difficulty and irritation of mucous membranes. Skin and eye irritant; may cause burns.잠재적 노출
Hexachlorobutadiene is used as a sol vent; heat-transfer fluid; transformer fluid; hydraulic fluid; as a solvent for elastomers; as a wash liquor for removing higher hydrocarbons.Carcinogenicity
In rats given oral administration, it produced benign and malignant tumors in the kidneys in both sexes. The IARC then concluded that there is limited evidence that HCBD is carcinogenic in rats.Nakagawa et al. reported that HCBD is a potent nephrotoxicant that selectively damaged the straight portion (pars recta) of the proximal tubule in the rat. They also reported administering 0.1% HCBD for 30 weeks to male Wistar rats previously given 0.1% N-ethyl-N-hydroxyethylnitrosamine (EHEN) in their drinking water for 2 weeks and that the combined treatment resulted in a significantly higher incidence of renal cell tumors than when EHEN was administered alone.
환경귀착
Chemical/Physical. Hexachlorobutadiene will not hydrolyze to any reasonable extent (Kollig, 1993).At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 258, 91, 21, and 11 mg/g, respectively (Dobbs and Cohen, 1980).
신진 대사 경로
In the presence of glutathione (GSH), mouse liver microsomes and cytosol transform 14C-hexachloro- 1,3-butadiene (HCBD) to S- (pentachlorobutadienyl)glutathione (PCBG). PCBG formation in subcellular fractions from a mouse kidney is very limited. After an oral dose of HCBD to mice, PCBG in feces, and S-(pentachlorobutadienyl)-L- cysteine, N-acetyl-S-(pentachlorobutadienyl)-L- cysteine, and 1,1,2,3-tetrachlorobutenoic acid in the urine are identified as the metabolites.운송 방법
UN2279 Hexachlorobutadiene, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.Purification Methods
Wash the diene with four or five 1/10th volumes of MeOH (or until the yellow colour has been extracted), then stir it for 2hours with H2SO4, wash it with distilled water until neutral and filter it through a column of P2O5. Distil it under reduced pressure through a packed column. [Rytner & Bauer J Am Chem Soc 82 298 1960, Beilstein 1 IV 998.]비 호환성
Strong reaction with oxidizers, aluminum powder. Attacks aluminum; some plastics, rubber and coatings폐기물 처리
High temperature incineration with flue gas scrubbing. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.헥사클로로부타디엔 준비 용품 및 원자재
원자재
준비 용품
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