다이메틸디클로로실란, 실리카와의 반응 생성물

다이메틸디클로로실란, 실리카와의 반응 생성물 속성

다이메틸디클로로실란, 실리카와의 반응 생성물 C화학적 특성, 용도, 생산

화학적 성질

Hydrophobic colloidal silica occurs as a light, fine, white or almost white amorphous powder, not wettable by water.

생산 방법

Hydrophobic colloidal silica is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 1800°C using a hydrogen–oxygen flame. It is rapidly cooled to create an amorphous productand immediately treated with dichlorodimethyl silane in a fluid bed reactor. The resulting surface is covered with dimethylsilyl groups. Aerosil R972 is manufactured by modifying the surface of Aerosil 130 and thus has the same primary particle size and surface area, but the density of silanol groups is reduced from approximately 2.0 SiOH/nm2 to 0.75 SiOH/nm2.

Pharmaceutical Applications

large specific surface area, which provide desirable flow characteristics in dry powders used in tableting and capsule filling. The hydrophobic grades absorb less moistureand may offer an advantage in moisture-sensitive formulations.
Hydrophobic colloidal silica is also used to thixotropically control viscosity, to thicken and stabilize emulsions, or as a suspending agent in gels and semisolid preparations. Hydrophobic colloidal silica has a less pronounced effect on solution viscosity but can thicken and stabilize the oil phase of a water–oil emulsion. With other ingredients of similar refractive index, transparent gels may be formed. Generally, the uses and ranges of hydrophobic colloidal silica are similar to the concentrations used of the standard hydrophilic colloidal silicon dioxide.

Safety

The safety profile of hydrophobic colloidal silica is the same as for the hydrophilic silica types, as the modified silica surface does not significantly alter the toxicological properties.
LD50 (rat, IV): 0.015 g/kg

저장

Hydrophobic colloidal silica should be stored in a well-closed container. It will not absorb moisture but may still absorb volatile substances owing to its high surface area.

비 호환성

Use of the hydrophobic colloidal silica Aerosil R972 reduces the strength of starch-based tablets.

Regulatory Status

Approved for use in pharmaceuticals in Europe. Approved by FDA and Europe for food contact articles. Included in nonparenteral medicines (oral tablets; rectal suppositories) licensed in the UK.

다이메틸디클로로실란, 실리카와의 반응 생성물 준비 용품 및 원자재

원자재

준비 용품

다이메틸디클로로실란, 실리카와의 반응 생성물 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	81	58
Hunan aslsen technology co.,ltd	+8619310186019	aslsb@aslsen.com	China	128	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12477	58
Hebei Zhanyao Biotechnology Co. Ltd	15369953316 +8615369953316	admin@zhanyaobio.com	China	2136	58

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