Arbidol

Arbidol C화학적 특성, 용도, 생산

개요

Arbidol, or umifenovir, an indole-derivative with broad-spectrum activity against both enveloped and non-enveloped viruses,was initially approved in China and Russia for the treatment of influenza A and B.Arbidol is believed to block the entry of influenza virus (A and B) into the host cells by increasing the stability of the hemagglutinin (HA) and hampering low pH reorganizations necessary for fusion machinery of hemagglutinin with the membrane.Arbidol could interfere with advanced stages of the viral life cycle, in that it is capable of interacting with both viral proteins and lipids.Regarding its structure, the presence of amine in position 4 and the hydroxyl moiety in position 5 is crucial for its antiviral activity. It is reported that 40% of the drug could be excreted unchanged after the administration while its half-life is between 17 and 21h.

용도

Umifenovir is an intermediate in synthesizing Arbidol Sulfoxide (A766005), a metabolite of Arbidol (A766000) which is a medicinal agent for treating viral infections.

생물학적 활성

Arbidol Arbidol is a broad spectrum antiviral. Displays activity against a range of respiratory and hepatitis viruses including influenza A, B and C, adenovirus, and hepatitis B and C. Increases stability of influenza viral hemagglutinins (HA) and prevents low-pH HA transition so inhibiting viral fusion. Also inhibits SARS-CoV-2 infection in vitro (IC50 = 4.11 μM).

Mechanism of action

Probable Mechanism of Action
lt is hypothesized that arbidol inhibits the contact between the virus and host cell that further prevents the entry of the virus into host cells. It is also being predicted that arbidol also interferes with the late stages of virus cycle by interacting with lipids and proteins of the virus which are essential for the viral replication;probably arbidol binds with these essential components that further inhibit viral replication (Boriskin et al., 2008).
Umifenovir inhibits membrane fusion.Umifenovir prevents contact between the virus and target host cells. Fusion between the viral envelope (surrounding the viral capsid) and the cell membrane of the target cell is inhibited. This prevents viral entry to the target cell, and therefore protects it from infection.
Some evidence suggests that the drug’s actions are more effective at preventing infections from RNA viruses than infections from DNA viruses.
As well as specific antiviral action against both influenza A and influenza B viruses, umifenovir exhibits modulatory effects on the immune system. The drug stimulates a humoral immune response, induces interferon-production, and stimulates the phagocytic function of macrophages.
https://newdrugapprovals.org

Clinical Use

Arbidol in Treatment of covID-19
Although,arbidol is not approved by US-FDA for the treatment of cOVID-19,some pre-clinical and clinical studies have reported that it may be a very efficacious therapeutic molecule for COVID-19 (Deng et al.,2020; Wang et al.,2020).Arbidol has been included in the latest version of the guidelines issued by the National Health Commission (NHC) of the people's republic of China for the prevention, diagnosis, and treatment of novel coronavirus induced pneumonia at the recommended dose of 200 mg, 3 times/day for 10 days for adults (National Health Commission,China).
An in-vitro study claimed that arbidol is effective against COVID-19 at the concentration range of 10-30 uM (News: Abidol and darunavir can effectively inhibit corona virus (2020). A retrospective study conducted by Deng and colleagues reported that patients who received oral arbidol plus lopinavir/ritonavir showed improvement in clinical symptoms and reduced viral load as a compared to the patients who received lopinavir/ritonavir alone (Deng et al.，2020).A randomized multi-centre controlled clinical trial of arbidol in the patients with cOVID-19 is currently running in China (ChiCTR2000029573).
Besides this, one more study was conducted on 69 patients of COVID-19.In this study, it was reported that the administration of arbidol at the dose of 0.4 g,TID for 9 days improves the discharging rate from the hospital and also decreases the mortality rate of patients (Wang et al.，2020). In addition，another study also reported that arbidol is more superior to the combination therapy of lopinavir/ritonavir (Zhu et al.，2020).
Arbidol: a broad-spectrum antiviral compound that blocks viral fusion
Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein

Arbidol 준비 용품 및 원자재

원자재

준비 용품

Arbidol 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Nanjing Fred Technology Co., Ltd	+86-25-84696168 +86-15380713688	Austin@fredbio.com	China	2449	58
Casorganics US Corp	+17326109938	sales@casorganics.com	CHINA	174	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	968	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3422	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
Hebei Binshare New Material Co. Ltd	+8618633865755	china01@hbbinshare.com	CHINA	969	58
Hebei Lihe Biotechnology Co.,ltd	86-311-80292533 13315122300	sales@lihebiotech.com	CHINA	305	58

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