Rosiglitazone
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Rosiglitazone 속성
- 녹는점
- 153-155 C
- 끓는 점
- 585.0±35.0 °C(Predicted)
- 밀도
- 1.315±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥10mg/mL
- 산도 계수 (pKa)
- 6.34±0.50(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- Merck
- 14,8265
- CAS 데이터베이스
- 122320-73-4(CAS DataBase Reference)
- IARC
- 3 (Vol. 108) 2016
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/38 | ||
| 안전지침서 | 26-37/39 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | XJ5813850 | ||
| HS 번호 | 2934100000 | ||
| 유해 물질 데이터 | 122320-73-4(Hazardous Substances Data) |
Rosiglitazone C화학적 특성, 용도, 생산
용도
Rosiglitazone is an insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).Indications
Rosiglitazone is approved for use as monotherapy and in conjunction with metformin, though it is sometimes combined with a sulfonylurea or insulin. It is usually taken once or twice a day with or without food. Rosiglitazone may cause a modest increase in lowdensity lipoprotein and triglyceride concentrations, but it is unclear whether this effect has any clinical significance or persists in the long term.일반 설명
Rosiglitazone is 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, and is availableas the maleate salt in tablets containing the drug alone(Avandia) or in combination products with metformin(Avandamet) or with glimepiride (Avandaryl). The2-aminopyridine moiety allows for salt formation; the marketedformulations contain the 1:1 salt with maleic acid, inwhich the pyridine nitrogen accepts a proton, forming the2-aminopyridinium species.Clinical Use
Although rosiglitazone is extensively biotransformed—playing the major role in both transformations, and some involvementof CYP2C9.21,47 The sulfate conjugate M10 is thepredominant circulating metabolite by 4-hour postdose. Theextraordinarily high plasma protein binding of this metabolite(and the N-demethylated sulfate conjugate M4) in humans accountsfor the lengthy residence time of the radioactivity in thebody, despite the relatively short pharmacokinetic half-life(4–4.5 hours) of rosiglitazone itself.Rosiglitazone 준비 용품 및 원자재
원자재
N,N-다이메틸폼아마이드
1.4-다이옥세인
플루오르벤젠알데히드
2,4-티아졸리딘 디온
수소
2-N-Methyl-2-pyridylaminoethanol
Piperidinium acetate
Acetic acid, [4-(hydroxymethyl)phenoxy]-, ethyl ester
196810-03-4
Pioglitazone
4-[2-[METHYL(PYRIDINE-2-YL)AMINO]ETHOXY]-BENZALDEHYDE
5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]benzylidene]-2,4-thiazolidinedione
4-히드록시벤질 알콜
Rosiglitazone Related Compound A (25 mg) ((5Z)-5-{[4-({2-[methyl(2-pyridinyl)amino]ethyl}oxy)phenyl]methylidene}-1,3-thiazolidine-2,4-dione)
2-플루오로피리딘
2-클로로피리딘
준비 용품
Rosiglitazone 공급 업체
글로벌( 468)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 |
erin@hbldbiotech.com | China | 878 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
Rosiglitazone 관련 검색:
3-아미노피리딘 살리실산 메틸 티오판산-메틸 2-아미노피리딘 4-다이메틸아미노피리딘 쿠레톡심메틸 브롬화 메틸 2,4-티아졸리딘 디온
Tribenuron methyl
PHENYL VALERATE
METSULFURON METHYL
Pioglitazone hydrochloride
Methyl
ROSIGLITAZONE HYDROCHLORIDE 99%,Rosiglitazone hydrochloride
rosiglitazone sodium
ROSIGLITAZONE MALEATE
2-[(N-METHYL-N-2-PYRIDINYL) AMINO]ETHANOL (FOR ROSIGLITAZONE)
Thiazole