눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P321
(…) 처치를 하시오.
P330
입을 씻어내시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
AMILORIDE C화학적 특성, 용도, 생산
개요
Amyloride is also a potassium sparing diuretic that exhibits moderate activity. It is not an
antagonist of aldosterone. It inhibits reabsorption of sodium ions and reduces excretion of potassium ions.
용도
Amiloride is an epithelial sodium channel blocker.
정의
ChEBI: A monocarboxylic acid amide that is N-carbamimidoylpyrazine-2-carboxamide substituted by amino groups at positions 3 and 5 and a chloro group at position 6.
Clinical Use
Amiloride, another potassium-sparing diuretic, is an aminopyrazine structurally related to triamterene as an open-chain analogue. Similar to triamterene, it interferes with
the process of cationic exchange in the distal convoluted tubule by blocking luminal sodium channels. It blocks the reabsorption of sodium ion and the secretion of
potassium ion. It has no effect on the action of aldosterone. Oral amiloride is approximately 50% absorbed, with
a duration of action of 10 to 12 hours, which is slightly longer than that for triamterene. Although triamterene is extensively metabolized, approximately 50% of amiloride
is excreted unchanged. Renal impairment can increase its elimination half-life. Like triamterene, amiloride combined with a thiazide or loop diuretic is used to treat edema
or hypertension.
