7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 속성
- 녹는점
- 244.0 to 248.0 °C
- 끓는 점
- 455.8±45.0 °C(Predicted)
- 밀도
- 1.167
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 클로로포름 (약간 용해됨), DMSO (약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 13.29±0.20(Predicted)
- 색상
- 미색부터 페일 베이지까지
- LogP
- 1.23 at 23℃ and pH6.47
- 표면장력
- 71mN/m at 36.9mg/L and 19℃
- CAS 데이터베이스
- 73942-87-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 2914390090 |
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one C화학적 특성, 용도, 생산
용도
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.주요 응용
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 준비 용품 및 원자재
원자재
HOMOVERATRYL CHLORIDE
Ivabradine related compound 9
N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
(3,4-Dimethoxyphenyl)acetic acid
준비 용품
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 공급 업체
글로벌( 302)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd | +86-010-83386758 +86-18810831598 |
jennifer@lianben.com | China | 85 | 58 |
Jiangsu Yutian pharmaceutical Co.,Ltd. | +undefined-0518-86098006 +undefined19851887368 |
lvan.hui@jsytsw.com | China | 80 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5988 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 14764 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21700 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 |
alice@jndxj.com | China | 303 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 관련 검색:
Ivabradine Impurity 70
4,5-Dimethoxy-1-cyanobenzocyclobutane
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
(Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
1204612-29-2
3,4-dimethoxy-N-methylbenzamide
8-DeMethyl Ivabradine
N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
Hydroxy Ivabradine
(3,4-Dimethoxyphenyl)acetic acid
C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE
Ivabradine Impurity 49
1132079-01-6
N-DeMethyl Ivabradine Hydrochloride
Ivabradine Impurity 1 Hydrochloride
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
7-DeMethyl Ivabradine