O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-
O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 구조식 이미지
카스 번호:
32986-56-4
한글명:
O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-
동의어(한글):
O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D-
상품명:
Tobramycin
동의어(영문):
Tobramycin Base;Tobramycine;tobra;nebcin;tobrex;Tobramax;nf6;obracin;Tobracin;nebicina
CBNumber:
CB7154445
분자식:
C18H37N5O9
포뮬러 무게:
467.52
MOL 파일:
32986-56-4.mol
MSDS 파일:
SDS

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 속성

녹는점
178 °C
알파
D20 +129° (c = 1 in water)
끓는 점
570.01°C (rough estimate)
밀도
1.3458 (rough estimate)
굴절률
143 ° (C=4, H2O)
저장 조건
Keep in dark place,Inert atmosphere,2-8°C
용해도
H2O: 50 mg/mL, 투명, 희미한 노란색
산도 계수 (pKa)
pKa 6.7 (Uncertain);8.3 (Uncertain);9.9 (Uncertain)
물리적 상태
흰색에서 회백색 고체
색상
흰색에서 황백색까지
수용성
물에 용해됨
Merck
14,9490
BRN
1357507
안정성
흡습성
안전
  • 위험 및 안전 성명
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-37/39
WGK 독일 2
RTECS 번호 WK2100000
F 고인화성물질 3-10
HS 번호 29419090
유해 물질 데이터 32986-56-4(Hazardous Substances Data)
독성 LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles)
기존화학 물질 KE-01283
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2 0

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- MSDS


Tobramycin

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- C화학적 특성, 용도, 생산

개요

Tobramycin is one component (factor 6) of a mixture produced by fermentation of Streptomyces tenebrari us. Lacking the C-3′ hydroxyl group, it is not a substrate for APH(3′)-1 and APH(3′)-II and so has an intrinsically broader spectrum than kanamycin. It is a substrate, however, for adenylation at C-2′ by ANT (2′) and acetylation at C-3 by AAC(3)-I and AAC(3)-II and at C-2′ by AAC(2′).

화학적 성질

White or almost white powder.

용도

Tobramycin is an aminoglycoside antibiotic.

정의

ChEBI: A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.

Indications

Tobramycin is highly active with respect to Gram-negative microorganisms (blue-pus bacillus and gastric bacilli, rabbit fever, serratia, providencia, enterobacteria, proteus, salmonella, shigella), as well as Gram-positive microorganisms (staphylococci, including those resistant to penicillin and some cephalosporins), and a few strains of streptococci.
It is used for severe bacterial infections: peritonitis, sepsis, meningitis, osteomyelitis, endocarditis, pneumonia, pleural empyema, pulmonary abscess, purulent skin infections and soft tissue infections, and infections of the urinary tract caused by microorganisms that are sensitive to the drug. Synonyms of this drug are nebicine, obracine, and others.

Antimicrobial activity

In-vitro activity against Ps. aeruginosa is usually somewhat greater than that of gentamicin; against other organisms activity is similar or a little lower. Other Pseudomonas species are generally resistant, as are streptococci and most anaerobic bacteria. Other organisms usually susceptible in vitro include Acinetobacter, Legionella and Yersinia spp. Alkaligenes, Flavobacterium spp. and Mycobacterium spp. are resistant. It exhibits bactericidal activity at concentrations close to the MIC and bactericidal synergy typical of aminoglycosides in combination with penicillins or cephalosporins.

원료

It is inactivated by many aminoglycoside-modifying enzymes that inactivate gentamicin. However, AAC(3′)-I does not confer tobramycin resistance and AAC(3′)-II confers a lower degree of tobramycin resistance than of gentamicin resistance. Conversely, ANT(4′) confers tobramycin but not gentamicin resistance, as do some types of AAC(6′). Overproduction of APH(3′), conferring a low degree of resistance to tobramycin (MIC 8 mg/L), but not gentamicin (MIC 2 mg/L), was ascribed to ‘trapping’ rather than phosphorylation.
Resistance rates are generally similar to those of gentamicin, although they may vary locally because of the prevalence of particular enzyme types.

생물학적 활성

Pharmacologically, tobramycin is quite similar to gentamicin. The drug is somewhat more active against Ps. aeruginosa than gentamicin. Tobramycin also acts synergistically with penicillin, but to a lesser degree than gentamicin.

Clinical Use

Severe infections caused by susceptible micro-organisms Ps. aeruginosa infections, including chronic pulmonary infections in cystic fibrosis (administration by injection or nebulizer)
For practical purposes use is identical to that of gentamicin, except possibly for Pseudomonas infection, where it has somewhat greater activity against gentamicin-susceptible and some gentamicin-resistant strains. Its value as a substitute for gentamicin in the speculative treatment of severe undiagnosed infection is offset by its lower activity against other organisms that may be implicated.
It has been used extensively to treat Ps. aeruginosa infections in patients with cystic fibrosis.

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 준비 용품 및 원자재

원자재

준비 용품


O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 공급 업체

글로벌( 400)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666
sales@hbmojin.com China 12409 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21703 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8823 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
CHINA 968 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47464 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29827 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290
1056@dideu.com China 3965 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9641 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58

O-3-아미노-3-디옥시-알파-D-글루코피라노실-(1→6)-O-[2,6-디아미노-2,3,6-트리디옥시-알파-D-헥소피라노실-(1→4)]-2-디옥시-D- 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved