2-(chloromethyl)-4-methylquinazoline

2-(chloromethyl)-4-methylquinazoline 구조식 이미지
카스 번호:
109113-72-6
상품명:
2-(chloromethyl)-4-methylquinazoline
동의어(영문):
Quinazoline,2-(chloroMethyl)-4-Methyl-;Linaint-I;Linagliptin INT3;Linagliptin Impurity 67;Linagliptin interMediate A;CHLOROMETHYL)-4-METHYLQUINAZOLINE;2-chloroMethyl-4-Methyl quinaoline;2-(chloromethyl)-4-methylquizoline;Linagliptin 2-Chloromethyl Impurity;2-(chloromethyl)-4-methylquinazolin
CBNumber:
CB71648970
분자식:
C10H9ClN2
포뮬러 무게:
192.64
MOL 파일:
109113-72-6.mol

2-(chloromethyl)-4-methylquinazoline 속성

녹는점
61.0 to 65.0 °C
끓는 점
240.0±32.0 °C(Predicted)
밀도
1.251
증기압
0Pa at 20℃
저장 조건
under inert gas (nitrogen or Argon) at 2–8 °C
용해도
클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
powder to crystal
산도 계수 (pKa)
1.86±0.50(Predicted)
색상
Light yellow to Yellow to Orange
수용성
3.11g/L at 20℃
최대 파장(λmax)
318nm(EtOH)(lit.)
InChIKey
UHCUBOJGMLASBY-UHFFFAOYSA-N
LogP
1.9 at 25℃
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
유엔번호(UN No.) 3261
위험 등급 8
포장분류 III
HS 번호 2933998090
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
3 0

2-(chloromethyl)-4-methylquinazoline C화학적 특성, 용도, 생산

화학적 성질

White to yellow powder

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1263, 1986 DOI: 10.1002/jhet.5570230458

Synthesis

Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%
2-(chloromethyl)-4-methylquinazoline

2-(chloromethyl)-4-methylquinazoline 준비 용품 및 원자재

원자재

준비 용품


2-(chloromethyl)-4-methylquinazoline 공급 업체

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