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(S)-4-Methyl-2,5-oxazolidonedione

(S)-4-Methyl-2,5-oxazolidonedione 구조식 이미지

카스 번호:: 2224-52-4

상품명:: (S)-4-Methyl-2,5-oxazolidonedione

동의어(영문):: ALA-NCA;L-Ala-NCA;L-Alanine N-Carbxy anhydride;(S)-4-METHYL-OXAZOLIDINE-2,5-DIONE;H-ALA-NCA;Alanine, NCA;L-Alanine NC;L-ALA-NCA(2224-52-4);Creatinine Impurity 3;L-Ala-N-Carboxyanhydride

CBNumber:: CB7180875

분자식:: C4H5NO3

포뮬러 무게:: 115.09

MOL 파일:: 2224-52-4.mol

속성

안전

용도

공급 업체 137

(S)-4-Methyl-2,5-oxazolidonedione 속성

녹는점: 92℃

알파: +5.13°(25/D,c=6.4,dioxane)

밀도: 1.296

저장 조건: Inert atmosphere,Store in freezer, under -20°C

용해도: DMSO(아주 약간 용해됨, 가열됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 9.38±0.40(Predicted)

색상: 흰색에서 황백색까지

InChI: InChI=1S/C4H5NO3/c1-2-3(6)8-4(7)5-2/h2H,1H3,(H,5,7)/t2-/m0/s1

InChIKey: DTETYCNJKAUROO-REOHCLBHSA-N

SMILES: O1C(=O)[C@H](C)NC1=O

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2934999090

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H332	흡입하면 유해함	급성 독성 물질 흡입	구분 4	경고	P261, P271, P304+P340, P312
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

(S)-4-Methyl-2,5-oxazolidonedione C화학적 특성, 용도, 생산

용도

(S)-4-Methyl-2,5-oxazolidonedione is composed of oxazolidine ring and 2,5-dione ring. It exhibits chirality, meaning it exists as two non-superimposable mirror image forms. Therefore, it can be used as an organic reagent for the synthesis of enantiomeric pure substances. (S)-4-Methyl-2,5-oxazolidonedione is a reagent used in the synthesis of poly(γ-benzyl-L-glutamate) and its block polypeptides with alanine, leucine and phenylalanine.

생산 방법

L-alanine (20.0 g, 0.224 mol) and triphosgene (53.4 g, 0.180 mol) were suspended in 400.0 mL of dry THF bubbled with nitrogen flux in a flame-dried three-neck flask. The mixture was stirred at 60 °C for 2 h before further bubbling with nitrogen flux for 30 min. After that, the solution was precipitated in 1000.0 mL of n-hexane and stored at -20 °C. The supernatant was removed, and the residues were collected and dissolved in 200.0 mL of ethyl acetate, before two washings with 100.0mL of ice-cold water and one washing with 100.0 mL of 0.5% NaHCO3 ice-cold aqueous solution. The organic phase was then dried over anhydrous MgSO4 and evaporated to obtain 15.5 g of L-Ala NCA ((S)-4-Methyl-2,5-oxazolidonedione). The yield of L-Ala NCA was 77.5%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 2200, 1985 DOI: 10.1021/jo00212a042

(S)-4-Methyl-2,5-oxazolidonedione 준비 용품 및 원자재

원자재

Di-tert-butyl Tricarbonate N-(tert-Butoxycarbonyl)-L-alanine L-Alanine, N-(methoxycarbonyl)- (9CI) N-Carbobenzyloxy-L-alanine L-알라닌 트리포스겐 클로로포름 다이포스젠

준비 용품

L-Alanyl-L-proline

(S)-4-Methyl-2,5-oxazolidonedione 공급 업체

글로벌( 137)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8618980456393	daisy@enlaibio.com	China	1369	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

(S)-4-Methyl-2,5-oxazolidonedione 관련 검색:

3-(3,5-다이클로로페닐)-5-에텐일-5-메틸-2,4-옥사졸리딘다이온 FMOC-ALA-N-CARBOXYANHYDRIDE Ethyl (S)-2-[(S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutyrate 5-METHYL-2,4-OXAZOLIDINEDIONE FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE BOC-O-BENZYL-L-SERINE N-CARBOXY ANHYDRIDE NALPHA-9-Fluorenylmethoxycarbonyl-L-leucine N-carboxylic anhydride BOC-ASP(OBZL)-N-CARBOXYANHYDRIDE BOC-L-ALANINE-NCA N-α-Fmoc-N-γ-trityl-L-asparagine N-carboxyanhydride BOC-O-BENZYL-L-THREONINE N-CARBOXY ANHYDRIDE FMOC-L-VALINE N-CARBOXY ANHYDRIDE N-α-Boc-N-ε-Z-L-lysine N-carboxyanhydride Fmoc-O-tert·butyl-L-threonineN-carboxyanhydride FMOC-ILE-N-CARBOXYANHYDRIDE BOC-TRYPTOPHAN NCA N-tert-Butoxycarbonyl-L-leucine N-carboxylic anhydride BOC-ILE-N-CARBOXYANHYDRIDE