VALINOMYCIN
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VALINOMYCIN 속성
- 녹는점
- 187-190 °C
- 알파
- D20 +31.0° (c = 1.6 in benzene)
- 끓는 점
- 821.74°C (rough estimate)
- 밀도
- 1.060
- 굴절률
- 1.6400 (estimate)
- 인화점
- 87℃
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥10 mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.32±0.70(Predicted)
- 색상
- 하얀색
- optical activity
- [α]20/D +32±2°, c = 1.6% in benzene
- 수용성
- 10mg/ml의 DMSO에 용해됩니다. 물에 불용성
- Merck
- 13,9976
- BRN
- 78657
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
| 위험품 표기 | Xn,T,T+,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 27/28-36/37/38-21/22 | ||
| 안전지침서 | 36-45-36/37-28-37/39-26 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 1 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | YV9468000 | ||
| F 고인화성물질 | 10-18-21 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | I | ||
| HS 번호 | 29419090 | ||
| 유해 물질 데이터 | 2001-95-8(Hazardous Substances Data) |
VALINOMYCIN C화학적 특성, 용도, 생산
화학적 성질
white crystalline powder용도
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.정의
ChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.일반 설명
Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.반응 프로필
VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).건강위험
VALINOMYCIN is highly toxic orally.화재위험
When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.생물학적 활성
Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .Purification Methods
Recrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]VALINOMYCIN 준비 용품 및 원자재
원자재
준비 용품
VALINOMYCIN 공급 업체
글로벌( 206)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 |
1057@dideu.com | China | 3537 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |