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VALINOMYCIN

VALINOMYCIN 구조식 이미지
카스 번호:
2001-95-8
상품명:
VALINOMYCIN
동의어(영문):
nsc122023;VALINOMYCIN;-valyl)[qr];valinomicin;nsc122023[qr];VALINOMYCIN 99%;valinomicin[qr];Valinomycin,90%;Valinomycin,96%;antibioticn-329b
CBNumber:
CB7199194
분자식:
C54H90N6O18
포뮬러 무게:
1111.32
MOL 파일:
2001-95-8.mol

VALINOMYCIN 속성

녹는점
186-190 °C
알파
D20 +31.0° (c = 1.6 in benzene)
끓는 점
821.74°C (rough estimate)
밀도
1.060
굴절률
1.6400 (estimate)
인화점
87℃
저장 조건
2-8°C
용해도
DMSO: ≥10 mg/mL
물리적 상태
solid
색상
white
optical activity
[α]20/D +32±2°, c = 1.6% in benzene
수용성
Soluble in DMSO at 10mg/ml. Insoluble in water
Merck
13,9976
BRN
78657
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T,T+,Xi
위험 카페고리 넘버 27/28-36/37/38-21/22
안전지침서 36-45-36/37-28-37/39-26
유엔번호(UN No.) UN 2811 6.1/PG 1
WGK 독일 3
RTECS 번호 YV9468000
F 고인화성물질 10-18-21
TSCA Yes
위험 등급 6.1(a)
포장분류 I
HS 번호 29419090
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 P264, P270, P301+P310, P321, P330,P405, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H310 피부와 접촉하면 치명적임 급성 독성 물질 - 경피 구분 1,2 위험 P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
예방조치문구:
P262 눈, 피부, 의복에 묻지 않도록 하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P310 즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P321 (…) 처치를 하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P302+P350 피부에 묻은 경우,비눗물로 부드럽게 씻기
P405 밀봉하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.

VALINOMYCIN C화학적 특성, 용도, 생산

화학적 성질

white crystalline powder

용도

Insecticide, nematocide, Patterson, Wright, US 3520973 (1970 to Am. Cyanamid).

용도

antibiotic; LD50 (rat, po) 4 mg/kg

용도

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta gonizes ET-induced vasoconstriction. Used as insecticide, nematocide.

용도

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

용도

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

정의

ChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.

일반 설명

Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.

반응 프로필

VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

건강위험

VALINOMYCIN is highly toxic orally.

화재위험

When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.

생물학적 활성

Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .

Purification Methods

Recrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]

VALINOMYCIN 준비 용품 및 원자재

원자재

준비 용품


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