Ethyl isocyanoacetate
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Ethyl isocyanoacetate 속성
- 끓는 점
- 194-196 °C (lit.)
- 밀도
- 1.035 g/mL at 25 °C (lit.)
- 증기압
- 61.7Pa at 25℃
- 굴절률
- n
20/D 1.418(lit.)
- 인화점
- 184 °F
- 저장 조건
- 2-8°C
- 용해도
- 에 용해됨클로로포름, 메탄올 (약간 용해됨)
- 물리적 상태
- 액체
- 색상
- 투명한 호박색에서 진한 갈색까지
- 수용성
- 유기용매와 섞일 수 있음. 물과 약간 섞임.
- 감도
- Moisture & Light Sensitive
- BRN
- 3588613
- 노출 한도
- NIOSH: IDLH 25 mg/m3
- LogP
- 0.91 at 25℃
- CAS 데이터베이스
- 2999-46-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/22-20/21/22 | ||
| 안전지침서 | 36/37/39-26-36/37-24/25 | ||
| 유엔번호(UN No.) | UN 2810 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 8-9-21 | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| HS 번호 | 29299090 |
Ethyl isocyanoacetate C화학적 특성, 용도, 생산
화학적 성질
Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.용도
Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.제조 방법
synthesis of ethyl isocyanoacetateA solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).
일반 설명
Material may darken upon storageEthyl isocyanoacetate 준비 용품 및 원자재
원자재
준비 용품
5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE
ETHYL3-METHYL-2-INDOLECARBOXYLATE
Diethyl 1H-pyrrole-2,4-dicarboxylate
ETHYL ISOTHIOCYANATOACETATE
ethyl 4-formyl-1H-pyrrole-2-carboxylate
ETHYL 5-(3-FLUOROPHENYL)-1,3-OXAZOLE-4-CARBOXYLATE
1-m-tolyl-1H-1,2,4-triazole-3-carboxylic acid
ETHYL 2-PHENYL-1-INDOLIZINECARBOXYLATE
Isocyanoacetic acid potassium salt
Ethyl 5-(diethoxyMethyl)-1H-iMidazole-4-carboxylate
Ethyl isocyanoacetate 공급 업체
글로벌( 235)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |