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3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 구조식 이미지

카스 번호:: 641569-96-2

상품명:: 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate

동의어(영문):: NILOTINIB IMPURITY 22;Nilotinib Impurity 35;Nilotinib Impurity 16(Nitrate);ethyl 3-guanidino-4-methylbenzoate;Ethyl 3-guanidino-4-methylbenzoate nitrate;Ethyl 3-Carbamimidoylamino-p-toluate Nitrate;2-Methyl-5-(ethylcarboxy)phenylguanidine nitrate;Ethyl 3-Carbamimidoylamino-4-methylbenzoate Nitrate;3-Carbamimidoylamino-p-toluic Acid Ethyl Ester Nitrate;Ethyl 3-Carbamimidoylamino-4-methylbenzoate Nitrate >

CBNumber:: CB72128666

분자식:: C11H16N4O5

포뮬러 무게:: 284.27

MOL 파일:: 641569-96-2.mol

속성

안전

용도

공급 업체 147

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 속성

녹는점: 197.0 to 201.0 °C

저장 조건: Sealed in dry,Room Temperature

물리적 상태: powder to crystal

색상: 흰색에서 거의 흰색

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2925.29.9000

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고		P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

NFPA 704

	0
1		0

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate C화학적 특성, 용도, 생산

화학적 성질

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Appearance white to almost white powder to crystals, melting point 199 °C, storage 2-8 °C.

용도

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate is an organic synthetic material or pharmaceutical intermediate compound that can be used in the preparation of N-phenyl-2-pyrimidinamine derivatives and in the synthesis of nilotinib and its salts. Nilotinib is a tyrosine kinase inhibitor used for the treatment of drug-resistant chronic myelogenous leukemia (CML), and in particular, for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myeloid leukemia (CML) in adult patients whose disease has progressed on or who cannot tolerate other therapies that included imatinib. Nilotinib is administrated as a hydrochloride salt in the form of capsules that are marketed in the USA and the EU under the name Tasigna?.

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 준비 용품 및 원자재

원자재

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester 3-Amino-4-methylbenzoic acid Ethyl 3-Amino-4-methylbenzoate Benzoic acid, 4-Methyl-3-nitro-, ethyl ester 3-니트로-p-톨루익산 시안아미드

준비 용품

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 공급 업체

글로벌( 147)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868	jennysun@yzqyyykj.com	China	64	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 관련 검색:

메틸 메타크릴에이트 다이메틸-p-페닐엔디아민 헥사메틸렌이민 트리스(하이드록시메틸)아미노메탄 글리신 벤조산에틸에스테르 초산에틸 에틸파라벤 Nilotinib Impurity 7 Nilotinib genotoxic impurity 3 Nilotinib Impurity 1 Nilotinib Impurity 20 3-Amino-4-methylbenzoic acid Nilotinib Impurity 28 Nilotinib impurity 3 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide Ethyl 4-hydroxybenzoate,sodium salt Tris(trimethylsilyl)phosphate