시프로플록사신

시프로플록사신
시프로플록사신 구조식 이미지
카스 번호:
85721-33-1
한글명:
시프로플록사신
동의어(한글):
시프로플록사신
상품명:
Ciprofloxacin
동의어(영문):
CIPROFLOXACIN BASE;Ciprofloxacine;Cipro;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3-QUINOLINECARBOXYLIC ACID;1-cyclopropyl-6-fluoro-7-(1-piperazinyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid;ciloxan;CIPROBAY;Ciprofloxacillin;CPFX;Baycip
CBNumber:
CB7217221
분자식:
C17H18FN3O3
포뮬러 무게:
331.34
MOL 파일:
85721-33-1.mol
MSDS 파일:
SDS

시프로플록사신 속성

녹는점
255-257°C
끓는 점
581.8±50.0 °C(Predicted)
밀도
1.461±0.06 g/cm3(Predicted)
저장 조건
Keep in dark place,Inert atmosphere,2-8°C
용해도
25mg/ml에서 0.1N HCl에 용해됩니다. DMSO에 잘 녹지 않음
산도 계수 (pKa)
pKa 4.04 (Uncertain)
물리적 상태
가루
색상
흰색에서 거의 흰색
수용성
86mg/L(25 ºC)
Merck
14,2314
BRN
3568352
CAS 데이터베이스
85721-33-1(CAS DataBase Reference)
EPA
Ciprofloxacin (85721-33-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36-24/25
유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 2
RTECS 번호 VB1993800
HS 번호 29339900
유해 물질 데이터 85721-33-1(Hazardous Substances Data)
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P273 환경으로 배출하지 마시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
1 0

시프로플록사신 C화학적 특성, 용도, 생산

용도

시프로플록사신(Ciprofloxacin)은 수많은 병균 감염을 치료하기 위해 사용되는 항생물질이다.여기에는 뼈 및 관절염, 복강내 전염, 특정한 종류의 장염, 호흡기 감염, 피부 감염, 장티푸스, 요로감염증 등이 포함된다. 일부 감염에 대해 다른 항생물질에 추가적으로 사용되기도 한다.

용도

구강으로, 안약으로, 정맥 주사로 복용할 수 있다.

개요

Ciprofloxacin is a quinolone antibacterial related to recently marketed norfloxacin (10), ofloxacin (2), pefloxacin (2) and enoxacin. It has a broad spectrum of activity against gram-positive and gram-negative bacteria, and is useful in the treatment of urinary and upper respiratory tract infections.

화학적 성질

White Powder

용도

Ciprofloxacin is used in the treatment of infections from a wide range of aerobic gram-positive and aerobic gramnegative microorganisms. It has been shown to be effective against inhalational anthrax and reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. It is also used in select respiratory infections, urinary tract infections, typhoid fever, some sexually transmitted diseases, and septicemia. Infectious diarrhea may be caused by organisms found in food or water and transferred by person-to-person contact. This may have a devastating effect, globally, especially in immunocompromised individuals. Ciprofloxacin is effective against those organisms that may contribute to infectious diarrhea, such as Escherichia coli (enterotoxigenic strains), Campylobacter jejuni, and select strains of Shigella; and is utilized when antibacterial therapy is medically indicated. Ciprofloxacin has also been utilized as a secondary agent in the treatment of tuberculosis.

정의

ChEBI: A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.

Antimicrobial activity

It exhibits potent activity against most Enterobacteriaceae, as well as against Acinetobacter spp. (MIC 0.25–1 mg/L), fastidious Gram-negative bacilli such as Mor. catarrhalis (MIC 0.06–0.25 mg/L) and Campylobacter jejuni(MIC 0.12 mg/L). In common with other quinolones, it is active against Bacillus anthracis. Ciprofloxacin is the most active quinolone against Ps. aeruginosa and exhibits good activity in vitro against other non-fermenting Gram-negative bacilli. In-vitro activity against Staph. aureus coagulase-negative staphylococci, Str. pyogenes, Str. pneumoniae and Enterococcus spp. (MIC c. 0.5–2 mg/L) is moderate. Most methicillin-resistant strains of staphylococci are resistant. It has poor activity against anaerobes, but is active against M. tuberculosis, Mycoplasma spp. and intracellular pathogens such as Chlamydia, Chlamydophila and Legionella.

Pharmaceutical Applications

A 6-fluoro, 7-piperazinyl quinolone formulated as the hydrochloride for oral administration and as the lactate for intravenous use.

부작용

Untoward reactions are uncommon, those encountered being typical of the group. Reactions severe enough to require withdrawal of treatment have occurred in <2% of patients. The most common reactions, gastrointestinal tract disturbances, have been seen in 5% of patients and rashes in about 1%. CNS disturbances typical of quinolones have been reported in 1–2% of patients. Tendinitis and tendon rupture (especially of the Achilles tendon) may occur in a small number of patients and ciprofloxacin should be avoided in patients at risk for these conditions. Potentiation of the action of theophylline and other drugs metabolized by microsomal enzymes may occur. Crystalluria and transient arthralgia have been reported.
In volunteers, dosages of up to 750 mg produced no change in the numbers of fecal streptococci and anaerobes, but did produce a 2.5 × log10 decline in the numbers of enterobacteria, which lasted 1 week. There was no change in the susceptibility of the affected organisms and no overgrowth by resistant strains. As with other quinolones, ciprofloxacin is not recommended for use in children or in pregnant or lactating women.
The drug should be avoided in suspected or confirmed infections caused by Str. pneumoniae. It is inferior to conventional agents and some other fluoroquinolones in the treatment of genital tract infections caused by C. trachomatis.
Ciprofloxacin has also been shown to be effective in the treatment of patients with malignant otitis externa, catscratch disease, prevention of infection in patients undergoing biliary tract surgery, and treatment of biliary tract infections. A topical preparation for use in the treatment of ocular infections is available, but is neither more effective nor safer than established topical agents; it may be indicated for superficial eye infections caused by pathogens resistant to conventional drugs or in patients unable to tolerate standard therapeutic agents.

환경귀착

The antimicrobial action of the drug is due to inhibition of the enzymes required for bacterial DNA function. Topoisomerase II (DNA gyrase) and topoisomerase IV are necessary for bacterial DNA replication, transcription, strand repair, and recombination. Thus, ciprofloxacin cytotoxicity may be caused by the loss of mtDNA encoded functions.

시프로플록사신 준비 용품 및 원자재

원자재

준비 용품


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