Hygroscopic, -20°C Freezer, Under Inert Atmosphere
용해도
DMSO: Soluble; Water: Soluble
물리적 상태
고체
안정성
흡습성
InChIKey
KFWHZSUNFAPZPW-NVIAPQDINA-M
안전
위험 및 안전 성명
위험 및 사전주의 사항 (GHS)
그림문자(GHS):
신호 어:
Danger
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H301
삼키면 유독함
급성 독성 물질 - 경구
구분 3
위험
P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P321
(…) 처치를 하시오.
P330
입을 씻어내시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
Mivacurium chloride C화학적 특성, 용도, 생산
개요
Mivacurium chloride,a mixture of three stereoisomers, is an intravenously
administered, short-acting skeletal muscle relaxant introduced as an adjunct to general
anesthesia. Structurally mivacurium chloride is closely related to doxacurium chloride
introduced in 1991 by Wellcome as a muscle relaxant. It is a nondepolarizing
neuromuscular blocking agent reportedly with a shorter duration of action and a more
rapid rate of spontaneous recovery than other nondepolarizing agents. In extensive
clinical trials mivacurium chloride was well tolerated with few side effects.
Mivacurium chloride (Mivacron) is a newer agent
that is chemically related to atracurium. The primary
mechanism of inactivation is hydrolysis by plasma
cholinesterase. Although it is useful for patients with
renal or hepatic disease, some caution is warranted,
since these individuals may have reduced plasma
cholinesterase as a result of the disease.Mivacurium has
an onset of action (1.8 minutes) and duration of effect
(20 minutes) only twice that of succinylcholine, and in
this respect, it is the most similar to succinylcholine of
all of the nondepolarizing agents.
일반 설명
Mivacurium chloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, (E)-4-octandioate (Mivacron), is a mixture of three stereoisomers,the trans-trans, cis-trans, and cis-cis diesters, each ofwhich has neuromuscular blocking properties. The cis-cisisomer is about one tenth as potent as the other isomers.Mivacurium chloride is a short-acting nondepolarizing drugused as an adjunct to anesthesia to relax skeletal muscle.The drug is hydrolyzed by plasma esterases, and it is likelythat anticholinesterase agents used as antidotes could prolongrather than reverse the effects of the drug.
