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Lornoxicam

Lornoxicam 구조식 이미지
카스 번호:
70374-39-9
상품명:
Lornoxicam
동의어(영문):
Xefo;Telos;TS 110;Xefocam;AKOS 93662;LORNOXICAM;Ro 13-9297;LornoxicaM API;chlortenoxicam;LornoxicaM (Xefo)
CBNumber:
CB7224647
분자식:
C13H10ClN3O4S2
포뮬러 무게:
371.82
MOL 파일:
70374-39-9.mol

Lornoxicam 속성

녹는점
225-230°C (dec.)
밀도
1.742±0.06 g/cm3(Predicted)
저장 조건
-20°C Freezer
용해도
DMSO: >5mg/mL (warmed)
산도 계수 (pKa)
pKa2 4.7(at 25℃)
물리적 상태
powder
색상
faint yellow to dark yellow
Merck
14,5582
InChIKey
WLHQHAUOOXYABV-UHFFFAOYSA-N
CAS 데이터베이스
70374-39-9(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,T+
위험 카페고리 넘버 36/37/38-28
안전지침서 26-36-45-36/37-28
유엔번호(UN No.) UN 2811 6.1 / PGII
WGK 독일 3
RTECS 번호 XJ9095000
위험 등급 IRRITANT
포장분류 II
HS 번호 29349990
독성 LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

Lornoxicam C화학적 특성, 용도, 생산

개요

Xefo, a member of the oxicam family of nonsteroidal antiinflammatory agents, was launched in Denmark for mild to moderate pain and inflammation. A seven step synthesis, beginning with 2,5-dichlorothiophene, provides access to this compound. It inhibits prostaglandin synthesis at the level of cyclooxygenase (Cox1 :Cox2 = 0.6) but does not inhibit 5-lipoxygenase. Xefo did not increase serum levels of pepsinogen I (an indicator of gastric mucosal status) and readily penetrates perivascular interstitial spaces including synovial fluid. It is as effective as morphine, meperidine and tramadol in relieving post operative pain and as efficient as other NSAlDs in relieving the symptoms of osteoarthritis and rheumatoid arthritis. It is 100 times more potent than Tenoxicam in inhibiting PGD2 and more active than indomethacin (6x) or piroxicam (10x) in preventing arachadonic acid influenced lethality in mice. Xefo has inhibitor effects on spinal nocicceptive processing presumably via release of endogenous opiods and evidence suggests it is good for migraine.

화학적 성질

Crystalline Solid

Originator

Nycomed Amersham (Norway)

용도

Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic

용도

keratolytic, antiacne, antineoplastic

용도

ocular vasoconstrictor

용도

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.

정의

ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.

상표명

Xefo

Lornoxicam 준비 용품 및 원자재

원자재

준비 용품


Lornoxicam 공급 업체

글로벌( 249)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30053 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 175 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20114 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales01@yibaibiotech.com CHINA 419 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35438 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47484 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 127809 58

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