4-아미노디페닐
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4-아미노디페닐 속성
- 녹는점
- 52-54 °C(lit.)
- 끓는 점
- 191 °C15 mm Hg(lit.)
- 밀도
- 1.1154 (rough estimate)
- 증기압
- 6 x 10-5 mmHg at 20–30 °C (quoted, Mercer et al., 1990)
- 굴절률
- 1.5785 (estimate)
- 인화점
- >110°C
- 저장 조건
- -20°C Freezer
- 용해도
- 디클로로메탄, DMSO 및 메탄올에 용해됨
- 산도 계수 (pKa)
- 4.35(at 18℃)
- 물리적 상태
- 가루
- 색상
- 갈색에서 진한 노란색까지
- 수용성
- 20~30°C에서 842mg/L(인용, Mercer et al., 1990)
- Merck
- 13,1235
- BRN
- 386533
- Henry's Law Constant
- (x 1010 atm?m3/mol): 3.89 at 25 °C (calculated, Mercer et al., 1990)
- 안정성
- 안정적이지만 공기 중의 산소와 천천히 반응합니다. 타기 쉬운. 강한 산화제, 산, 산 무수물, 산 염화물과 호환되지 않습니다.
- InChIKey
- DMVOXQPQNTYEKQ-UHFFFAOYSA-N
- CAS 데이터베이스
- 92-67-1(CAS DataBase Reference)
- IARC
- 1 (Vol. 1, Sup 7, 99, 100F) 2012
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 45-22-36/37/38-20/21/22 | ||
안전지침서 | 53-45-36-26 | ||
유엔번호(UN No.) | UN 3077 9/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DU8925000 | ||
자연 발화 온도 | 842 °F | ||
TSCA | Yes | ||
위험 등급 | 6.1(a) | ||
포장분류 | I | ||
HS 번호 | 29214990 | ||
유해 물질 데이터 | 92-67-1(Hazardous Substances Data) | ||
독성 | Acute oral LD50 for rats 200 mg/kg, mice 50 mg/kg (quoted, Verschueren, 1983). | ||
기존화학 물질 | KE-01326 | ||
유해화학물질 필터링 | 97-1-445;06-4-57 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 4-아미노비페닐 및 이를 0.1% 이상 함유한 혼합물 |
4-아미노디페닐 C화학적 특성, 용도, 생산
개요
4-Aminobiphenyl is an aromatic amine (arylamine) that exists at room temperature as a colorless crystalline solid with a floral odor. It is slightly soluble in cold water, but readily soluble in hot water. It is soluble in ethanol, ether, acetone, chloroform, and lipids. It oxidizes in air and emits toxic fumes when heated to decomposition (Akron 2009).물리적 성질
Colorless to yellow-brown crystalline solid with a floral-like odor. Becomes purple on exposure to air.용도
In the United States, 4-aminobiphenyl now is used only in laboratory research. It formerly was used commercially as a rubber antioxidant, as a dye intermediate, and in the detection of sulfates (HSDB 2009).정의
ChEBI: 4-Aminobiphenyl is an aminobiphenyl that is biphenyl substituted by an amino group at position 4. It has a role as a carcinogenic agent. It derives from a hydride of a biphenyl.일반 설명
Colorless to yellowish-brown crystals or light brown solid.공기와 물의 반응
Is oxidized by air (darkens on oxidation). Insoluble in water.반응 프로필
4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. . May react with strong oxidizing agents.위험도
Toxic by ingestion, inhalation, skin absorp- tion. Confirmed carcinogen. Bladder and liver can- cer.건강위험
4-Aminodiphenyl exposure is associated with a high incidence of bladder cancer in humans.화재위험
4-AMINOBIPHENYL is probably combustible.Safety Profile
Confirmed human carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. An irritant. Effects resemble those of benzidine. See also BENZIDINE. Slight to moderate fire hazard when exposed to heat, flames (sparks), or powerful oxidzers. To fight fire, use water spray, mist, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AROMATIC AMINES.잠재적 노출
4-Aminobiphenyl is no longer manufactured commercially and is only used for research purposes. 4-Aminobiphenyl was formerly used as a rubber antioxidant and as a dye intermediate. Is a contaminant in 2-aminobiphenyl.Carcinogenicity
4-Aminobiphenyl is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.Cancer of the urinary bladder was first reported to be associated with occupational exposure to 4-aminobiphenyl in a descriptive epidemiological study (published in the mid 1950s), in which 11% (19 of 171) of workers in a plant manufacturing 4-aminobiphenyl developed urinary-bladder cancer. These workers had been exposed to 4-aminobiphenyl for 1.5 to 19 years between 1935 and 1955. Publication of this study led to an effort to discontinue production and useof 4-aminobiphenyl. Starting in 1955, 541 workers who had been exposed to 4-aminobiphenyl were followed for an additional 14 years; 43 men (7.9%) developed histologically confirmed urinary-bladder cancer. In a survey of workers at a plant producing a variety of chemicals, the risk of mortality from urinary-bladder cancer was elevated tenfold, and all of the men who died of urinary-bladder cancer had worked at the plant during the period when 4-aminobiphenyl was used (1941 through 1952). The International Agency for Research onCancer concluded that there was sufficient evidence of the carcinogenicity of 4-aminobiphenyl in humans (IARC 1972, 1987).
Since 4-aminobiphenyl was listed in the First Annual Report on Carcinogens, most research on its carcinogenicity has focused on exposure from cigarette smoking. Epidemiological studies have reported the incidence of urinary-bladder cancer to be 2 to 10 times as high among cigarette smokers as among nonsmokers. Higher levels of 4-aminobiphenyl adducts (4-aminobiphenyl metabolites bound to DNA or protein) were detected in bladder tumors (DNA adducts) and red blood cells (hemoglobin adducts) from smokers thanfrom nonsmokers (Feng et al. 2002). In a case-control study, levels of 4-aminobiphenyl–hemoglobin adducts were higher in smokers with urinary-bladder cancer than in a control group of similarly exposed smokers (Del Santo et al. 1991). A Taiwanese study reported that 4-aminobiphenyl–hemoglobin adducts were associated with increased risk of liver cancer (Wang et al. 1998).
환경귀착
4-Aminobiphenyl is one of a number of chemicals that cause methemoglobinemia, or conversion of hemoglobin to methemoglobin, which reduces the ability of the blood to carry oxygen to the tissues. In addition, the active metabolite is believed to produce cancer through its reaction with cellular DNA. In animal studies, the observed incidence of 4-aminobiphenyl adducts with bladder epithelium DNA correlated well with the observed bladder tumor incidence.신진 대사 경로
Ring oxidation of 4-aminobiphenyl occurred only to a minor extent in microsomes. In contrast, N-oxidation of 4,4'-methylene-bis-(2-chloroaniline) is preferentially catalyzed by the phenobarbital-induced enzymes P- 450PB-B and P-450PB-D to cause ring oxidation and methylene carbon oxidation. 4,4'-Methylene-bis-(2- chloroaniline) ring oxidation and methylene carbon oxidation show varied cytochrome P-450 selectivity and accounted for 14-79% of total oxidation products.운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name RequiredPurification Methods
Crystallise it from water or EtOH. [Beilstein 12 IV 3241.] CARCINOGENIC.비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides and acid anhydrides.폐기물 처리
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal devices.4-아미노디페닐 준비 용품 및 원자재
원자재
준비 용품
4-아미노디페닐 공급 업체
글로벌( 254)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Baynoe Chem (Suzhou) Co., Ltd. | +86-512 65869404 +86-18934593683 |
sales06@baynoe.com | China | 292 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12457 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 6710 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
xinshengkeji@xsmaterial.com | China | 1100 | 58 |
Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 |
info@spring-chem.com | China | 2068 | 57 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
4-아미노디페닐 관련 검색:
2-니트로플로렌 2-아세틸아미노플루오렌 2,7-디니트로-9-플루오레논 벤지딘 4-아미노비페닐 염산염
2-NITROFLUORENONE
2,7-Diaminofluorene dihydrochloride
2-AMINO-9-FLUORENOL
2-Aminofluorene
2,7-Dinitrofluorene
9-DICYANOMETHYLENE-2,4,7-TRINITROFLUORENE
2,4,5,7-TETRANITRO-9-FLUORENONE
2-Amino-7-bromofluorene
2-AMINO-9-FLUORENONE
2,4,7-TRINITRO-9-FLUORENONE
2-Aminobiphenyl
4-ACETYL-2-AMINOBIPHENYL
4ETHYL4AMINOBIPHENYL