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4-아미노디페닐

4-아미노디페닐
4-아미노디페닐 구조식 이미지
카스 번호:
92-67-1
한글명:
4-아미노디페닐
동의어(한글):
4-바이페닐아민;4-아미노디페닐;4-비페닐아민;4-아미노비페닐;비페닐-4-일아민;비페닐-4-일아민및그염류;비페닐-4-일아민;4-비페닐아민;제닐라민;4-아미노비페닐;제닐라민;(1,1'-바이페닐)-4-아민;(1,1'-바이페닐-4-일)아민;(1,1'-비페닐)-4-아민;[1,1'-바이페닐]-4-아민;4-아미노다이페닐;4-아미노바이페닐;p-아미노비페닐;p-젠닐아민;바이페닐-4-일아민;바이페닐아민
상품명:
4-Aminobiphenyl
동의어(영문):
4-adp;Of PCB;92-67-1;NSC 7660;Xenylamin;Xenylamine;p-Xenylamine;4-AMinobiphe;4-Bifenylamin;Biphenylamine
CBNumber:
CB7229899
분자식:
C12H11N
포뮬러 무게:
169.22
MOL 파일:
92-67-1.mol

4-아미노디페닐 속성

녹는점
52-54 °C(lit.)
끓는 점
191 °C15 mm Hg(lit.)
밀도
1.1154 (rough estimate)
증기압
6 x 10-5 mmHg at 20–30 °C (quoted, Mercer et al., 1990)
굴절률
1.5785 (estimate)
인화점
>110°C
저장 조건
-20°C Freezer
용해도
Soluble in Dichloromethane, DMSO and Methanol
산도 계수 (pKa)
4.35(at 18℃)
물리적 상태
powder
수용성
842 mg/L at 20–30 °C (quoted, Mercer et al., 1990)
Merck
13,1235
BRN
386533
Henry's Law Constant
(x 1010 atm?m3/mol): 3.89 at 25 °C (calculated, Mercer et al., 1990)
안정성
Stable, but slowly reacts with oxygen in the air. Combustible. Incompatible with strong oxidizing agents, acids, acid anhydrides, acid chlorides.
InChIKey
DMVOXQPQNTYEKQ-UHFFFAOYSA-N
CAS 데이터베이스
92-67-1(CAS DataBase Reference)
IARC
1 (Vol. 1, Sup 7, 99, 100F) 2012
NIST
4-Aminobiphenyl(92-67-1)
EPA
4-Aminobiphenyl (92-67-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,Xn
위험 카페고리 넘버 45-22-36/37/38-20/21/22
안전지침서 53-45-36-26
유엔번호(UN No.) UN 3077 9/PG 3
WGK 독일 3
RTECS 번호 DU8925000
자연 발화 온도 842 °F
TSCA Yes
위험 등급 6.1(a)
포장분류 I
HS 번호 29214990
유해 물질 데이터 92-67-1(Hazardous Substances Data)
독성 Acute oral LD50 for rats 200 mg/kg, mice 50 mg/kg (quoted, Verschueren, 1983).
기존화학 물질 KE-01326
유해화학물질 필터링 97-1-445;06-4-57
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 4-아미노비페닐 및 이를 0.1% 이상 함유한 혼합물
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
2 0

4-아미노디페닐 C화학적 특성, 용도, 생산

개요

4-Aminobiphenyl is an aromatic amine (arylamine) that exists at room temperature as a colorless crystalline solid with a floral odor. It is slightly soluble in cold water, but readily soluble in hot water. It is soluble in ethanol, ether, acetone, chloroform, and lipids. It oxidizes in air and emits toxic fumes when heated to decomposition (Akron 2009).

화학적 성질

4-Aminobiphenyl is a combustible, colorless to tan crystalline solid that turns purple on exposure to air. May be used in a liquid solution. Floral odor.

물리적 성질

Colorless to yellow-brown crystalline solid with a floral-like odor. Becomes purple on exposure to air.

용도

In the United States, 4-aminobiphenyl now is used only in laboratory research. It formerly was used commercially as a rubber antioxidant, as a dye intermediate, and in the detection of sulfates (HSDB 2009).

생산 방법

Because of its carcinogenic effects, 4-aminobiphenyl has not been produced commercially in the United States since the mid 1950s (Koss et al. 1969). It was present in the drug and cosmetic color additive D&C yellow no. 1; however, use of this color additive was discontinued in the late 1970s (HSDB 2009). 4-Aminobiphenyl has beenreported to be formed by the decomposition of 1,3-diphenyltriazeneproduced by the reaction of diazoaniline and aniline during manufacture of the dye D&C red no. 33 (Bailey 1985). In 2009, 4-aminobiphenyl (for use in research) was available from 11 U.S. suppliers, including one company that supplied bulk quantities (ChemSources 2009). 4-Aminobiphenyl also has been reported as a contaminant in diphenylamine (HSDB 2009).

정의

ChEBI: An aminobiphenyl that is biphenyl substituted by an amino group at position 4.

일반 설명

Colorless to yellowish-brown crystals or light brown solid.

공기와 물의 반응

Is oxidized by air (darkens on oxidation). Insoluble in water.

반응 프로필

4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. . May react with strong oxidizing agents.

위험도

Toxic by ingestion, inhalation, skin absorp- tion. Confirmed carcinogen. Bladder and liver can- cer.

건강위험

4-Aminodiphenyl exposure is associated with a high incidence of bladder cancer in humans.

화재위험

4-AMINOBIPHENYL is probably combustible.

Safety Profile

Confirmed human carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. An irritant. Effects resemble those of benzidine. See also BENZIDINE. Slight to moderate fire hazard when exposed to heat, flames (sparks), or powerful oxidzers. To fight fire, use water spray, mist, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AROMATIC AMINES.

잠재적 노출

4-Aminobiphenyl is no longer manufactured commercially and is only used for research purposes. 4-Aminobiphenyl was formerly used as a rubber antioxidant and as a dye intermediate. Is a contaminant in 2-aminobiphenyl.

Carcinogenicity

4-Aminobiphenyl is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.
Cancer of the urinary bladder was first reported to be associated with occupational exposure to 4-aminobiphenyl in a descriptive epidemiological study (published in the mid 1950s), in which 11% (19 of 171) of workers in a plant manufacturing 4-aminobiphenyl developed urinary-bladder cancer. These workers had been exposed to 4-aminobiphenyl for 1.5 to 19 years between 1935 and 1955. Publication of this study led to an effort to discontinue production and useof 4-aminobiphenyl. Starting in 1955, 541 workers who had been exposed to 4-aminobiphenyl were followed for an additional 14 years; 43 men (7.9%) developed histologically confirmed urinary-bladder cancer. In a survey of workers at a plant producing a variety of chemicals, the risk of mortality from urinary-bladder cancer was elevated tenfold, and all of the men who died of urinary-bladder cancer had worked at the plant during the period when 4-aminobiphenyl was used (1941 through 1952). The International Agency for Research onCancer concluded that there was sufficient evidence of the carcinogenicity of 4-aminobiphenyl in humans (IARC 1972, 1987).
Since 4-aminobiphenyl was listed in the First Annual Report on Carcinogens, most research on its carcinogenicity has focused on exposure from cigarette smoking. Epidemiological studies have reported the incidence of urinary-bladder cancer to be 2 to 10 times as high among cigarette smokers as among nonsmokers. Higher levels of 4-aminobiphenyl adducts (4-aminobiphenyl metabolites bound to DNA or protein) were detected in bladder tumors (DNA adducts) and red blood cells (hemoglobin adducts) from smokers thanfrom nonsmokers (Feng et al. 2002). In a case-control study, levels of 4-aminobiphenyl–hemoglobin adducts were higher in smokers with urinary-bladder cancer than in a control group of similarly exposed smokers (Del Santo et al. 1991). A Taiwanese study reported that 4-aminobiphenyl–hemoglobin adducts were associated with increased risk of liver cancer (Wang et al. 1998).

환경귀착

4-Aminobiphenyl is one of a number of chemicals that cause methemoglobinemia, or conversion of hemoglobin to methemoglobin, which reduces the ability of the blood to carry oxygen to the tissues. In addition, the active metabolite is believed to produce cancer through its reaction with cellular DNA. In animal studies, the observed incidence of 4-aminobiphenyl adducts with bladder epithelium DNA correlated well with the observed bladder tumor incidence.

신진 대사 경로

Ring oxidation of 4-aminobiphenyl occurred only to a minor extent in microsomes. In contrast, N-oxidation of 4,4'-methylene-bis-(2-chloroaniline) is preferentially catalyzed by the phenobarbital-induced enzymes P- 450PB-B and P-450PB-D to cause ring oxidation and methylene carbon oxidation. 4,4'-Methylene-bis-(2- chloroaniline) ring oxidation and methylene carbon oxidation show varied cytochrome P-450 selectivity and accounted for 14-79% of total oxidation products.

운송 방법

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Purification Methods

Crystallise it from water or EtOH. [Beilstein 12 IV 3241.] CARCINOGENIC.

비 호환성

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides and acid anhydrides.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal devices.

4-아미노디페닐 준비 용품 및 원자재

원자재

준비 용품


4-아미노디페닐 공급 업체

글로벌( 233)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Springchem New Material Technology Co.,Limited
021-62885108 +8613917661608
info@spring-chem.com China 2064 57
Henan DaKen Chemical CO.,LTD.
371-66670886
info@dakenchem.com China 15400 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
info@tianfuchem.com China 22022 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
fandachem@gmail.com China 9513 55
ATK CHEMICAL COMPANY LIMITED
21-51619050
ivan@atkchemical.com China 26810 60
AB PharmaTech,LLC
323-480-4688
sales01@abpharmatechusa.com United States 989 55
Beijing Green Guardee Technology Co., Ltd
86-010-69706062
sales2@greenguardee.com CHINA 650 58
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 13734021967
kaia@neputrading.com CHINA 1011 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29960 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
linda@hubeijusheng.com CHINA 28229 58

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