Unii-0789652qul
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Unii-0789652qul 속성
- 밀도
- 1.467±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥5mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.89±0.70(Predicted)
안전
| WGK 독일 | 3 |
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Unii-0789652qul C화학적 특성, 용도, 생산
개요
Mivotilate is an orally-active hepatoprotective agent introduced for the treatment of liver cirrhosis and hepatitis-B infection. It is a dithietanylidene malonate analogue of malotilate and is without the haemotological adverse effects associated with the latter. Mivotilate can be obtained by partial saponification of the corresponding diisopropylmalonate, conversion of the acid function into mixed anhydride then to the amide with an aminothiazole. It displays potent hepatoprotective activity in rat and mice liver injury models by a mechanism involving the inactivation of Kupffer cells. Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450 system, particularly to inhibit CYP2E1 expression and to up-regulate the CYP1A1 expression. The low oral bioavailability of Mivotilate in rats (F<0.22%) could be primarilly attributed to poor absorption and considerable hepatic and gastrointestinal first-pass effects. Mivotilate prevents mutagenesis caused by agents such as benzo[a]pyrene and reduces skin tumors induced by these agents.Originator
Yuhan Corp (South Korea)용도
Vasodilator (coronary).Unii-0789652qul 준비 용품 및 원자재
원자재
준비 용품
Unii-0789652qul 공급 업체
글로벌( 16)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 |
info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 |
liming@bio-fount.com | China | 9730 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44894 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 |
psaitong@jm-bio.com | China | 29834 | 58 |
| ChemeGen 中国 | 18818260767 |
sales@chemegen.com | China | 6975 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 |
sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24131 | 58 |