Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- 구조식 이미지
카스 번호:
168682-53-9
상품명:
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
동의어(영문):
CS-1110;Ezatiostat;Terrapin 199;Ezatiostat, >96%;Ezatiostat, >=98%;TER199(free base);Ezatiostat (TER199);Ezatiostat salt free;Ezatiostat 168682-53-9;Ezatiostat TFA (free base)
CBNumber:
CB72563432
분자식:
C27H35N3O6S
포뮬러 무게:
529.65
MOL 파일:
168682-53-9.mol
MSDS 파일:
SDS

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- 속성

녹는점
>94°C (dec.)
끓는 점
749.7±60.0 °C(Predicted)
밀도
1.216±0.06 g/cm3(Predicted)
저장 조건
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)
12?+-.0.46(Predicted)
물리적 상태
고체
물리적 상태
단단한 모양
색상
흰색에서 황백색까지

안전

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- C화학적 특성, 용도, 생산

개요

Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; Ki = 0.4 μM). It is selective for GSTP1-1 over GSTα and GSTμ family GSTs (Kis = 20-75 μM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in Gstp1 wild-type, but not Gstp1-/-, mice.

용도

Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1, the most prevalent Glutathione S-transferases (GST) isozyme in nonhepatic tissues, catalytic activity with minimal effect on the related GSTα and -μ families.

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- 준비 용품 및 원자재

원자재

준비 용품


Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- 공급 업체

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