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Vortioxetine hydrobromide

Vortioxetine hydrobromide 구조식 이미지

카스 번호:: 960203-27-4

상품명:: Vortioxetine hydrobromide

동의어(영문):: Vortioxetine HBr;1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine hydrobromide;Vortioxetin hydrobromide;CS-1537;AA21004;AA 21004;AA-21004;Lu AA21004 (HBr);Vortioxetine impurity L;Lu AA 21004 hydrobromide

CBNumber:: CB72614372

분자식:: C18H23BrN2S

포뮬러 무게:: 379.36

MOL 파일:: 960203-27-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 352

Vortioxetine hydrobromide 속성

녹는점: >223°C (dec.)

저장 조건: Refrigerator

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 페일베이지부터 라이트베이지까지

InChI: InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H

InChIKey: VNGRUFUIHGGOOM-UHFFFAOYSA-N

SMILES: S(C1C=CC(C)=CC=1C)C1C=CC=CC=1N1CCNCC1.Br

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	29339900

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H317	알레르기성 피부 반응을 일으킬 수 있음	피부 과민성 물질	구분 1	경고	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H410	장기적 영향에 의해 수생생물에 매우 유독함	수생 환경유해성 물질 - 만성	구분 1	경고	P273, P391, P501

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P272	작업장 밖으로 오염된 의복을 반출하지 마시오.
P273	환경으로 배출하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P321	(…) 처치를 하시오.
P330	입을 씻어내시오.
P333+P313	피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.
P363	다시 사용전 오염된 의류는 세척하시오.
P391	누출물을 모으시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
2		0

Vortioxetine hydrobromide C화학적 특성, 용도, 생산

용도

Vortioxetine Hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).

정의

ChEBI: Vortioxetine hydrobromide is a hydrobromide obtained by combining vortioxetine with one molar equivalent of hydrobromic acid. Used for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic antagonist and a serotonergic agonist. It contains a vortioxetine(1+).

Synthesis

As the picture 2 showed, we have developed a new and practical synthetic route to vortioxetine hydrobromide on a hectogram scale. Adopting commercially available materials, through simple and traditional steps, including nucleophilic substitution, catalytic hydrogenation, and cyclization of the piperazine ring, gave the final product in 63.2% yield over three steps and with 99.3% purity (HPLC). Purification methods for the intermediates involved in the route are also given.
Synthesis_960203-27-4

Pic.3 A new synthetic route to vortioxetine hydrobromide

Solubility in water

Vortioxetine hydrobromide is slightly soluble in water; at ambient temperature solubility is equivalent to approximately 1.3 mg base/mL, pH being 5.5 in the saturated solution.

Mode of action

Vortioxetine Hydrobromide is a hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine.

Vortioxetine hydrobromide 준비 용품 및 원자재

원자재

2,4-Dimethylbenzenethiol 보티옥세틴 2-PIPERAZIN-1-YL-PHENYLAMINE 2-((2,4-DiMethylphenyl)thio)phenylaMine 1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene BIS(2-BROMOETHYL)AMINE HYDROBROMIDE 4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 1-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine Hydrochloride 4-IODO-M-XYLENE 2-BROMOTHIOPHENOL

준비 용품

Vortioxetine hydrobromide 공급 업체

글로벌( 352)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Seasons Biotechnology Co., Ltd.	+86-0576-89232655 +86-13566878689	info@seasonsbio.com	China	46	58
Jewim Pharmaceutical (Shandong) Co., Ltd.	+86-15552509998 +86-15621883869	liutf@jewim.com.cn	China	251	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Guangzhou Tengyue Chemical Co., Ltd.	+86-86-18148706580 +8618826483838	evan@tyvovo.com	China	152	58
Jinan Million Pharmaceutical Co., Ltd	+86-531-68659554 +8613031714605	info@millionpharm.com	China	154	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55

Vortioxetine hydrobromide 관련 검색:

Unii-4bmh7izt98 tadalafi di(2,4-xylyl) disulphide Vorapaxar Sulfate Vortioxetine Vortioxetine iMpurity Wortoxime hydrobromide impurity F Pazopanib Selumetinib Axitinib Bexarotene Dasatinib Benztropine mesylate 1-[2-[(2,6-diMethylphenyl)thio]phenyl]- Piperazine Vortioxetine Impurity 34 Vortioxetine Impurity 25 Wortoxime hydrobromide impurity A Wortoxime Hydrobromide Impurity C