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LGK-974

LGK-974 구조식 이미지
카스 번호:
1243244-14-5
상품명:
LGK-974
동의어(영문):
LGK-974;CS-1102;WNT-974;NVP-LGK974;LGK974; LGK-974;LGK974 (WNT974);LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
CBNumber:
CB72655412
분자식:
C23H20N6O
포뮬러 무게:
396.44
MOL 파일:
1243244-14-5.mol

LGK-974 속성

끓는 점
650.9±55.0 °C(Predicted)
밀도
1.268±0.06 g/cm3(Predicted)
산도 계수 (pKa)
12.24±0.70(Predicted)

안전

LGK-974 C화학적 특성, 용도, 생산

개요

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

용도

LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.

LGK-974 준비 용품 및 원자재

원자재

준비 용품


LGK-974 공급 업체

글로벌( 87)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
ATK CHEMICAL COMPANY LIMITED
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Biochempartner
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