ChemicalBook >제품 카탈로그 >생화학 공학>억제제>줄기 세포 & Wnt>Wnt / 베타 카테닌 저해제>LGK-974

LGK-974

LGK-974 구조식 이미지

카스 번호:: 1243244-14-5

상품명:: LGK-974

동의어(영문):: LGK-974;WNT-974;CS-1102;NVP-LGK974;LGK974 (WNT974);LGK974; LGK-974;LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;7'-Dichlorodihydrofluorescein diacetate

CBNumber:: CB72655412

분자식:: C23H20N6O

포뮬러 무게:: 396.44

MOL 파일:: 1243244-14-5.mol

속성

안전

용도

공급 업체 112

LGK-974 속성

녹는점: 176 - 180°C

끓는 점: 650.9±55.0 °C(Predicted)

밀도: 1.268±0.06 g/cm3(Predicted)

저장 조건: Refrigerator

용해도: 클로로포름(약간 용해됨), 메탄올(약간 용해됨)

산도 계수 (pKa): 12.24±0.70(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 황백색까지

안전

HS 번호	2933399990

LGK-974 C화학적 특성, 용도, 생산

개요

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC₅₀ = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

용도

LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.

LGK-974 준비 용품 및 원자재

원자재

준비 용품

LGK-974 공급 업체

글로벌( 112)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

LGK-974 관련 검색:

N-Methylaniline Didecyl dimethyl ammonium chloride N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide xav-939 Wnt-C59 MG-132 Sunitinib Malate CHIR-99021 Olaparib