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NFPA 704
2
2
0
2-CHLORO-2,2-DIFLUOROACETOPHENONE C화학적 특성, 용도, 생산
개요
Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and
N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to
produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally
diverse phenol derivatives and N-heterocyclic compounds.
용도
2-Chloro-2,2-difluoroacetophenone can be used:
As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
일반 설명
2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.
