Diltiazem hydrochloride
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Diltiazem hydrochloride 속성
- 녹는점
- 212-214 °C
- 알파
- D24 +98.3 ± 1.4° (c = 1.002 in methanol)
- 밀도
- 1.30 g/cm3
- 굴절률
- 118 ° (C=1, H2O)
- 인화점
- 2℃
- 저장 조건
- 2-8°C
- 용해도
- 물, 메탄올 및 염화메틸렌에 잘 녹고, 무수 에탄올에는 약간 녹습니다.
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수소이온지수(pH)
- pH (10g/l, 25℃) : 4.3～5.3
- 수용성
- 녹는
- Merck
- 13,3226
- BRN
- 4228706
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 증류수에 용해된 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 33286-22-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-40-36/37/38-36-20/21/22-11 | ||
| 안전지침서 | 36-45-36/37-26-16 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | DL0310000 | ||
| F 고인화성물질 | 8-10 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29349990 | ||
| 독성 | LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972) | ||
| 기존화학 물질 | KE-00136 |
Diltiazem hydrochloride MSDS
(+)-cis-3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)one monohydrochloride
Diltiazem hydrochloride C화학적 특성, 용도, 생산
화학적 성질
Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450.98. Diltiazem hydrochloride injection is a clear, colorless, sterile, nonpyrogenic solution. It has a pH range of 3.7 to 4.1.용도
An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils정의
ChEBI: Diltiazem hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension. It has a role as an antihypertensive agent, a vasodilator agent and a calcium channel blocker. It contains a diltiazem(1+). It is an enantiomer of an ent-diltiazem hydrochloride.일반 설명
Diltiazem hydrochloride is a calcium ion cellular influx inhibitor. It was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.
생물학적 활성
Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.Mode of action
Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.Diltiazem hydrochloride 준비 용품 및 원자재
원자재
프로피온산에틸
2-Chloroethyldimethylamine
Aza
2-아미노티오페놀
모노클로로초산에틸
중탄산나트륨(중조)
아니스알데히드
염산
나트륨 에톡시드
무수초산
DESACETYL DILTIAZEM HCL
Deacetyldiltiazem
[S-(R*,R*)]-3-[(o-aminophenyl)thio]-3-(p-methoxyphenyl)lactic acid
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
준비 용품
Diltiazem hydrochloride 공급 업체
글로벌( 527)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
| Shanghai Jinhuan Chemical CO.,LTD. | +86-21-52210535 +8613162045318 |
sales@jinhchem.com | China | 332 | 58 |
| Suzhou Sanyi Polymer Chemical Technology Co., Ltd. | +8615571922873 |
15571922873@163.com | China | 106 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 152 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
| Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 +86-13082019107 |
admin@flanderff.com | China | 229 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |