A chemical extracted from Evodia plants, and has been shown to reduce fat uptake.
Anticancer Research
The fruit of Evodia rutaecarpa Benth. is a standout among the most prominent andmultipurpose herbs utilized in China for pharmacological application (Fei et al.2003). Phytochemical analysis demonstrated that evodiamine, an indole alkaloid,exists in elevated amounts in Chinese herb evodia. This has wide-ranging biologicalactivities with vasodilatory, anti-obesity, anticancer, and anti-inflammatoryeffects (Jiang and Hu 2009). Evodiamine represses PDGF-BB-induced vascularsmooth muscle cell proliferation in a dose-dependent manner. It inhibits cell cycleprogression by suppressing the activation of p38 and Erk/MAPK pathway andameliorates ROS generation (Yang et al. 2008b; Heo et al. 2009; Yang et al. 2013).Restraint of mitogenesis and p38/p Erk action may fill in as the molecular basis forthe capacity of evodiamine. Evodiamine causes continued initiation of Erk/MAPKsignaling pathway in 3T3-L1 and essential preadipocytes prompting a potentinhibitory impact for adipogenesis (Wang et al. 2008). The consequence of thisinvestigation showed that evodiamine hindered vascular smooth muscle cell(VSMC) multiplication by stifling cell cycle movement, p38 MAPK and Erk 1/2enactment, and generation of ROS. Moreover, evodiamine offers the potential oftreating cardiovascular infections connected with the strange expansion of vascularsmooth muscle cells.
