와파린소듐;쿠마린,3-(알파-아세토닐벤질)-4-하이드록시-,소듐염 C화학적 특성, 용도, 생산
화학적 성질
Colorless solid
용도
Warfarin Sodium (Crystalline Clathrate) is used for pharmaceutical care for patients with chronic heart failure and renal dysfunction.
일반 설명
Slightly bitter crystalline powder. An anticoagulant used as a rodenticide.
반응 프로필
A coumarin derivative, a lactone. Lactones are similar to esters reactive chemistries.
건강위험
Warfarin sodium is highly toxic orally in humans.
화재위험
When heated to decomposition, Warfarin sodium emits toxic fumes of sodium oxide.
Clinical Use
By virtue of its great potency, warfarin sodium at firstwas considered unsafe for use in humans and was used veryeffectively as a rodenticide, especially against rats. At theproper dosage level, however, it can be used in humans, especiallythrough the intravenous route.
Safety Profile
Poison to humans by
ingestion. Experimental poison by ingestion
and intravenous routes. Human systemic
effects by ingestion: dermatitis. Human
reproductive effects by ingestion:
fetotoxicity, abnormal condition of newborn
at birth, other newborn physical effects, and
teratogenic effects includmg developmental
abnormalities of the eye and ear, craniofacial
area, skin and appendages, musculoskeletal
system, cardiovascular system, and
gastrointestinal system of the fetus. ,4n
experimental teratogen. Other experimental
reproductive effects. Mutation data
reported. An anticoagulant drug. When
heated to decomposition it emits toxic
fumes of Na2O.
