11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 속성
- 녹는점
- 235-238°C
- 끓는 점
- 591.5±50.0 °C(Predicted)
- 밀도
- 1.38±0.1 g/cm3(Predicted)
- 증기압
- 0Pa at 25℃
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.93±0.70(Predicted)
- 색상
- 흰색에서 밝은 노란색
- 수용성
- 815mg/L at 20℃
- LogP
- 0.8 at 25℃
- CAS 데이터베이스
- 13951-70-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione C화학적 특성, 용도, 생산
화학적 성질
White Crystalline SolidSynthesis
501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 준비 용품 및 원자재
원자재
준비 용품
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 공급 업체
글로벌( 346)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 |
790226113@qq.com | China | 52 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10991 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 관련 검색:
프레드니손 프레드니솔원
9,11-Anhydrobudesonide
Di-Norbudesonide (Mixture of DiastereoMers)
Budesonide Sulfate SodiuM (Mixture of DiastereoMers)
14,15-Dehydro Budesonide
9α-BroMobudesonide
16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione
(Mixture of DiastereoMers)
Desonide
Budesonide
Budesonide EP Impurity D (Mixture of Diastereomers)
21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione
1,2-Dehydrobudesonide
Budesonide Impurity 1 (Mixture of Diastereomers)
Budesonide EP Impurity A-d4
Flunisolide
(r)-budesonide