Cefotiam
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Cefotiam 속성
- 끓는 점
- 843℃
- 밀도
- 1.80±0.1 g/cm3(Predicted)
- RTECS 번호
- XI0366000
- 인화점
- >110°(230°F)
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- 2.57±0.50(Predicted)
- 수용성
- 녹는
- CAS 데이터베이스
- 61622-34-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 신호 어: | Danger | ||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Cefotiam C화학적 특성, 용도, 생산
용도
Antibacterial정의
ChEBI: A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalospo in antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.Antimicrobial activity
A semisynthetic cephalosporin formulated as the dihydrochloride for injection and as a prodrug ester, cefotiam hexetil, for oral administration. Activity is similar to that of cefuroxime, but it is somewhat more active against a range of enterobacteria .A 30-min intravenous infusion of the dihydrochloride produces a peak serum concentration of 35 mg/L; the corresponding concentration after a 1 g intramuscular dose is 17 mg/L. Oral absorption of the hexetil ester is around 65%. Food delays absorption of the ester. The plasma half-life is 0.6–1.1 h. Around 40% is bound to plasma protein. Urinary excretion is almost complete 4 h after the end of intravenous infusion, but only 50–67% is recovered unchanged; there is substantial non-renal elimination and some evidence of saturation of renal tubular excretion at doses above 2 g. In anuria the plasma elimination half-life rises to 13 h and plasma and renal clearances parallel creatinine clearance. A small amount is excreted in bile. In patients with cholelithiasis given 0.5 or 1 g intravenously, mean concentrations in gallbladder bile and gallbladder wall 30 min after the dose were around 17 and 32 mg/L, respectively. In patients with normal liver function, hepatic bile concentrations can exceed 1 g/L.
It is generally well tolerated and has been used successfully to treat lower respiratory infections, skin and soft-tissue infection. It is not widely used, but is available in Japan and some other countries.
Cefotiam 준비 용품 및 원자재
원자재
Cefotiam Hydrochloride
2-N-BUTOXYETHYL METHACRYLATE
MERCAPTANS
1H-TETRAZOLE
소디움 아지이드
(+)-MENTHYL CHLOROFORMATE
이산화탄소
이소티오시안산에틸에스테르
황산마그네슘
2-아미노-4-티아졸아세트 산
염산 히드록실아민
트리에틸아민
AMBERLITE
1-[2-(다이메틸아미노)에틸]-1,2-다이하이드로-5H-테트라졸-5 -티온
N-히드록시석신이미드
준비 용품
Cefotiam 공급 업체
글로벌( 88)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 775 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9604 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29525 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15747 | 58 |
Cefotiam 관련 검색:
P-다이메틸아미노벤즈알데하이드 3-(디메틸아미노)프로필아민 6-아미노 카프로산 2,4-펜탄디온 아세틸 보조 효소 A 트리스(하이드록시메틸)아미노메탄 글리신 아세틸 염화물 4-다이메틸아미노벤조산 4-다이메틸아미노피리딘 (6R-trans)-7-[2-(2-아미노티아졸-4-일)아세타미도]-3-[[[1-[2-(디메틸아미노)에틸]-1H-테트라졸-5-일]티오]메틸]-8-옥소-5-티아-1-아자바이사이클로[4.2.0]옥트-2-엔-2-카복실릭산 디하이드로클로라이드 2-디메틸아미노에탄올 2-아미노-4-티아졸아세트 산 1-[2-(다이메틸아미노)에틸]-1,2-다이하이드로-5H-테트라졸-5 -티온
2-(2-Aminothiazol-4-yl)glyoxylic acid
N-ACETYL-L-TYROSINE ETHYL ESTER
ALTRENOGEST
CefotiaM Hexetil Hydrochloride