미녹시딜

미녹시딜
미녹시딜 구조식 이미지
카스 번호:
38304-91-5
한글명:
미녹시딜
동의어(한글):
미녹시딜;6-(피페리다이닐)-2,4-피리미딘다이아민-3-옥사이드(미녹시딜),그염류및유도체
상품명:
Minoxidil
동의어(영문):
Minoxidil Base;pdp;Minoxidil powder;2,4-diamino-6-piperidinopyrimidine3-n-oxide;rogaine;minoxidi;Minoxidil CRS;4-pyrimidinediamine;Minoxidil for system suitability;Minoxidil for system suitability CRS
CBNumber:
CB7383531
분자식:
C9H15N5O
포뮬러 무게:
209.25
MOL 파일:
38304-91-5.mol
MSDS 파일:
SDS

미녹시딜 속성

녹는점
272-274 °C (dec.) (lit.)
끓는 점
348.61°C (rough estimate)
밀도
1.1651 (rough estimate)
굴절률
1.7610 (estimate)
저장 조건
2-8°C
용해도
물에 약간 용해되고 메탄올과 프로필렌 글리콜에 용해됩니다.
산도 계수 (pKa)
4.61(at 25℃)
색상
하얀색
수용성
물(2.2 mg/ml), 100% 에탄올(29 mg/ml), 프로필렌 글리콜, 아세톤, DMSO(6.5 mg/ml) 및 메탄올에 용해됩니다.
Merck
14,6203
BCS Class
3
안정성
최대 3개월 동안 -20°C에서 DMSO 또는 에탄올에 보관
InChIKey
ZFMITUMMTDLWHR-UHFFFAOYSA-N
CAS 데이터베이스
38304-91-5(CAS DataBase Reference)
NIST
Minoxidil(38304-91-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T+
위험 카페고리 넘버 22-36/37/38-26/27/28
안전지침서 26-36-45-36/37/39-22
WGK 독일 3
RTECS 번호 UV8200000
HS 번호 29335990
유해 물질 데이터 38304-91-5(Hazardous Substances Data)
독성 LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra)
기존화학 물질 KE-01301
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

미녹시딜 MSDS


6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide

미녹시딜 C화학적 특성, 용도, 생산

개요

Minoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.

화학적 성질

White Crystalline Solid

용도

Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels

정의

ChEBI: Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a pyrimidine N-oxide, a member of piperidines and an aminopyrimidine.

일반 설명

Minoxidil, 2,4-diamino-6-piperidinopyrimidine-3-oxide . It is converted to minoxidil sulfate in the liver bya sulfotransferase enzyme.
The antihypertensive properties of minoxidil are similarto those of hydralazine hydrochloride, in that minoxidil candecrease arteriolar vascular resistance. Minoxidil exerts itsvasodilatory action by a direct effect on arteriolar smoothmuscle and appears to have no effect on the CNS or on theadrenergic nervous system in animals. The serum half-lifeis 4.5 hours, and the antihypertensive effect may last up to24 hours.

생물학적 활성

Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.

Pharmacokinetics

Minoxidil is absorbed from the GI tract and is metabolized to its active sulfate metabolite. Plasma concentrations for minoxidil sulfate peak within 1 hour and then decline rapidly. Following an oral dose of minoxidil, its hypotensive effect begins in 30 minutes, is maximal in 2 to 8 hours, and persists for approximately 2 to 5 days. The delayed onset of the hypotensive effect for minoxidil is attributed to its metabolism to its active metabolite. The drug is not bound to plasma proteins. The major metabolite for minoxidil is its N-O-glucuronide, which unlike the sulfate metabolite is inactive as a hypotensive agent. Approximately 10 to 20% of an oral dose of minoxidil is metabolized to its active metabolite, minoxidil O-sulfate, and approximately 20% of minoxidil is excreted unchanged.

Clinical Use

Minoxidil is used for severe hypertension that is difficultto control with other antihypertensive agents. The drug hassome of the characteristic side effects of direct vasodilatorydrugs. It causes sodium and water retention and may requirecoadministration of a diuretic. Minoxidil also causes reflextachycardia, which can be controlled by use of a -adrenergicblocking agent.
Minoxidil topical solution is used to treat alopecia androgenitica(male-pattern baldness). Although the mechanismis not clearly understood, topical minoxidil is believed to increasecutaneous blood flow, which may stimulate hairgrowth. The stimulation of hair growth is attributed to vasodilationin the vicinity of application of the drug, resultingin better nourishment of the local hair follicles.

부작용

Adverse reactions include local irritation and contact dermatitis. If the treatment is discontinued, clinical regression occurs within 3 months to the state of hair thinning that would have occurred had the treatment not been started. Twice-daily treatment is more efficacious than once-daily application. Women who use the5%concentrationmay note the development of facial hair, which is reversible on discontinuation of the medication. The 5% concentration can be more irritating than the 2% solution.

Drug interactions

When minoxidil is administered with diuretics or other hypotensive drugs, the hypotensive effect of minoxidil increases, and concurrent use may cause profound orthostatic hypotensive effects.

미녹시딜 준비 용품 및 원자재

원자재

준비 용품


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