세프타졸린 나트륨
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세프타졸린 나트륨 속성
- 녹는점
- 190 °C
- 굴절률
- 20 ° (C=10, H2O)
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- H2O: 50 mg/mL, 투명, 무색
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 황백색까지
- 감도
- Light Sensitive
- Merck
- 14,1917
- BRN
- 3585038
- 안정성
- 안정적이지만 열에 민감할 수 있으므로 서늘한 곳에 보관하세요. 빛에 노출되면 변색될 수 있으므로 어두운 곳에 보관하세요. 강한 산화제와 호환되지 않습니다.
- InChIKey
- LJIOGPYKTPCRAP-MVOALHSDNA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)CN3N=NN=C3)C(=O)N12)CSC1=NN=C(C)S1)(=O)O.[NaH] |&1:5,7,r|
- LogP
- 1.133 (est)
- CAS 데이터베이스
- 27164-46-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 42/43-36/37/38-20/21/22 | ||
| 안전지침서 | 22-36/37-36-26 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | XI0390000 | ||
| HS 번호 | 29349990 | ||
| 독성 | LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead) | ||
| 기존화학 물질 | KE-25358 |
세프타졸린 나트륨 C화학적 특성, 용도, 생산
개요
Cefazolin was synthesized by Fujisawa Pharmaceutical Co. in 1969. It was the first of the cephem antibiotics to introduce a thiadiazolylthiomethyl group at the 3 position and a tetrazole group at the 7 position in the side chain. Cefazolin is a parenteral cephem antibiotic showing better activity against gramnegative bacteria than cephalothin or cephaloridine. Its bactericidal activity, tissue distribution, and urinary excretion are excellent and it has wide clinical use.화학적 성질
White to off-white powder용도
Semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. An antibacterial정의
ChEBI: A cephalosporin organic sodium salt having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.Clinical Use
Cefazolin (Ancef, Kefzol) is one of a series of semisyntheticcephalosporins in which the C-3 acetoxy function has beenreplaced by a thiol-containing heterocycle—here, 5-methyl-2-thio-1,3,4-thiadiazole. It also contains the somewhatunusual tetrazolylacetyl acylating group. Cefazolin wasreleased in 1973 as a water-soluble sodium salt. It is activeonly by parenteral administration.Cefazolin provides higher serum levels, slower renalclearance, and a longer half-life than other first-generationcephalosporins. It is approximately 75% protein bound inplasma, a higher value than for most other cephalosporins.Early in vitro and clinical studies suggest that cefazolin ismore active against Gram-negative bacilli but less activeagainst Gram-positive cocci than either cephalothin orcephaloridine. Occurrence rates of thrombophlebitis followingintravenous injection and pain at the site of intramuscularinjection appear to be the lowest of the parenteralcephalosporins.
세프타졸린 나트륨 준비 용품 및 원자재
원자재
1-페닐-1H-테트라졸-5-티올
5-메틸-1,3,4-티아디아졸-2-티올
1H-Tetrazole-1-acetic acid
7-Aminocephalosporanic acid
수산화나트륨
중탄산나트륨(중조)
1H-TETRAZOLE-1-ACETYL CHLORIDE
5-Methyl-1,3-benzenediacetonitrile
준비 용품
세프타졸린 나트륨 공급 업체
글로벌( 420)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shenzhen Excellent Biomedical Technology Co.,Ltd. | +86-0755-26050679 +86-15915472436 |
sale@ex-biotech.cn | China | 1031 | 58 |
| Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 |
admin@china-yime.com | China | 563 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 893 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 2259 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |