ANHYDROTETRACYCLINE HYDROCHLORIDE

ANHYDROTETRACYCLINE HYDROCHLORIDE 구조식 이미지
카스 번호:
13803-65-1
상품명:
ANHYDROTETRACYCLINE HYDROCHLORIDE
동의어(영문):
AnhydrotetracyclineHCl;Tetracycline Anhydro HCl;Aureomycin EP impurity J;Anhydrotetracycline HCl, EvoPure;ANHYDROTETRACYCLINE HYDROCHLORIDE;5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE;Anhydrotetracycline hydrochloride CRS;Anhydrotetracycline hydrochloride ,97%;ANHYDROTETRACYCLINE HYDROCHLORIDE USP/EP/BP;Lymecycline Impurity 3(Lymecycline EP Impurity C)
CBNumber:
CB7438626
분자식:
C22H23ClN2O7
포뮬러 무게:
462.88
MOL 파일:
13803-65-1.mol

ANHYDROTETRACYCLINE HYDROCHLORIDE 속성

녹는점
223 °C
RTECS 번호
QI7860000
저장 조건
Refrigerator
용해도
에탄올, DMSO 또는 DMF에 용해됨
물리적 상태
가루
색상
노란색에서 밝은 노란색까지
감도
Moisture Sensitive
BRN
4228856
안정성
흡습성
EPA
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 63-36
안전지침서 36/37/39-26
WGK 독일 3
HS 번호 29413020
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P403 환기가 잘 되는 곳에 보관하시오.

ANHYDROTETRACYCLINE HYDROCHLORIDE C화학적 특성, 용도, 생산

개요

The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.

화학적 성질

yellow to bright yellow powder

용도

Anhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.

ANHYDROTETRACYCLINE HYDROCHLORIDE 준비 용품 및 원자재

원자재

준비 용품


ANHYDROTETRACYCLINE HYDROCHLORIDE 공급 업체

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