트리아세틴

트리아세틴 속성

트리아세틴 MSDS

1,2,3-Triacetoxypropane

트리아세틴 C화학적 특성, 용도, 생산

용도

Triacetin 가장 중요 한 최종 사용이, 차례 차례로, 항목으로 그 효과 불포화 폴리에스터 수 지의 생산에 우리의 일상 생활, 물 탱크, 또는 범선 처럼 우리의 여가 시간입니다. Triacetin는 또한 가소제, 표면 활성 제, 유화 제 및 demulsifying 에이전트, 형 억제 물, 과일, 얼음 제와 수 분 유지 담배에 대 한 에이전트에 대 한 살 균으로 사용할 수 있습니다.

순도시험

  (1) 비중 : 이 품목의 비중은 1.154～1.158이어야 한다.

  (2) 굴절률 : 이 품목의 굴절률 는 1.429～1.431이어야 한다.

  (3) 산도 : 이 품목 약 25g을 정밀히 달아 중화알콜 50mL에 녹이고 페놀프탈레인시액 5방울을 가한 다음 0.02N 수산화나트륨용액으로 엷은 홍색이 30초간 유지될 때까지 적정할 때, 그 소비량은 1.0mL 이하이어야 한다.

  (4) 불포화물 : 이 품목 10mL에 황색이 나타날 때까지 브롬•클로로포름용액(1→100)을 적하하고 암소에서 18시간 방치할 때, 혼탁해지거나 침전물이 생겨서는 아니 된다.

  (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

  (6) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

확인시험

  (1) 이 품목 수 방울을 시험관에 취하고 황산수소칼륨 약 0.5g을 가하여 가열하면 아클로레인의 자극적인 증기가 발생한다.

  (2) 이 품목의 정량법에서 얻은 액은 확인시험법 중 초산염의 반응을 나타낸다.

정량법

  이 품목 약 1g을 정밀히 달아 적당한 압력에 견디는 병에 취하고 1N 수산화칼륨용액 25mL 및 이소프로필알콜 15mL를 가한 다음 마개를 하고 98±2℃의 수욕조에서 액이 잠기도록 1시간 가열한다. 식힌 다음 과잉의 알칼리를 0.5N 황산으로 적정한다

    (지시약 : 페놀프탈레인시액 6～8 방울). 따로 같은 방법으로 공시험을 한다.

0.5N 황산 1mL ＝ 36.37mg C₉H₁₄O₆

강열잔류물

  이 품목의 강열잔류물은 0.02% 이하이어야 한다.

개요

§ 184.1901(a) Triacetin (C8H14O6), also known as 1,2,3-propanetriol triacetate or glyceryl triacetate, is the triester of glycerin and acetic acid. Triacetin can be prepared by heating glycerin with acetic anhydride alone or in the presence of finely divided potassium hydrogen sulfate. It can also be prepared by the reaction of oxygen with a liquid-phase mixture of allyl acetate and acetic acid using a bromide salt as a catalyst.

화학적 성질

Triacetin is a colorless, viscous liquid with a slightly fatty odor.

출처

Reported found in papaya.

용도

As fixative in perfumery; solvent in manufacture of celluloid, photographic films. Technical triacetin (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.

정의

ChEBI: A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.

제조 방법

By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.

생산 방법

Triacetin is prepared by the esterification of glycerin with acetic anhydride.

일반 설명

Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams, nonalcoholic beverages and baked goods.

Pharmaceutical Applications

Triacetin is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.
Triacetin is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.

색상 색인 번호

Triacetin is a component of cigarette filters, which induced a contact dermatitis in a worker at a cigarette manufactory.

Clinical Use

Glyceryl triacetate (Enzactin, Fungacetin) is a colorless, oilyliquid with a slight odor and a bitter taste. The compound issoluble in water and miscible with alcohol and most organicsolvents.
The activity of triacetin is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin. Acid release is a self-limiting process becausethe esterases are inhibited below pH 4.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. An eye irritant. Combustible when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Triacetin is used in oral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels employed as an excipient.
LD50 (dog, IV): 1.5 g/kg
LD50 (mouse, IP): 1.4 g/kg
LD50 (mouse, IV): 1.6 g/kg
LD50 (mouse, oral): 1.1 g/kg
LD50 (mouse, SC): 2.3 g/kg
LD50 (rabbit, IV): 0.75 g/kg
LD50 (rat, IP): 2.1 g/kg
LD50 (rat, oral): 3 g/kg
LD50 (rat, SC): 2.8 g/kg

in vitro

Litton Bionetics, Inc. (1976) evaluated the mutagenic potential of Triacetin in a plate test using Salmonella typhimurium strains TA1535, TA1537, and TA1538 with and without metabolic activation. Test concentrations were 0.0013%, 0.00065%, and 0.000325% and the solvent was dimethyl sulfoxide (DMSO). A negative control (solvent) and appropriate positive controls were used and gave expected results. Triacetin was not mutagenic with or without metabolic activation.
Unichema Chemie B.V. (1994) reported that Triacetin was not mutagenic at 50 to 5000 μg/plate in an Ames test using S. typhimurium strains TA1535, TA1537, TA98, and TA100 with and without metabolic activation.

저장

Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.

비 호환성

Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules and tablets and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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트리아세틴 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Anhui Royal Chemical Co., Ltd.	+86-25-86655873 +8613962173137	marketing@royal-chem.com	China	142	55
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	893	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55

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