CALPHOSTIN C

CALPHOSTIN C 구조식 이미지
카스 번호:
121263-19-2
상품명:
CALPHOSTIN C
동의어(영문):
UCN-1028C;2-Diazole;PKF 115-584;CALPHOSTIN C;Cladochrome E;(R)-Calphostin C;Calphostin C,98%;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384
CBNumber:
CB7457711
분자식:
C44H38O14
포뮬러 무게:
790.76
MOL 파일:
121263-19-2.mol
MSDS 파일:
SDS

CALPHOSTIN C 속성

끓는 점
1039.8±65.0 °C(Predicted)
밀도
1.48±0.1 g/cm3(Predicted)
저장 조건
-20°C
용해도
DMF: 1mg/mL
물리적 상태
가루
산도 계수 (pKa)
7.30±0.20(Predicted)
색상
빨간색에서 갈색으로

안전

위험품 표기 Xn
위험 카페고리 넘버 20/21/22-36/37/38
안전지침서 24/25-36-26
WGK 독일 3
HS 번호 29209010
유해 물질 데이터 121263-19-2(Hazardous Substances Data)

CALPHOSTIN C C화학적 특성, 용도, 생산

화학적 성질

Dark red solid

용도

Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

생물학적 활성

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).

CALPHOSTIN C 준비 용품 및 원자재

원자재

준비 용품


CALPHOSTIN C 공급 업체

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