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NFPA 704
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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid C화학적 특성, 용도, 생산
화학적 성질
white crystalline low melting solid
용도
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.
일반 설명
Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.
Purification Methods
A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid 준비 용품 및 원자재
