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카보시스테인

카보시스테인
카보시스테인 구조식 이미지
카스 번호:
638-23-3
한글명:
카보시스테인
동의어(한글):
카보시스테인
상품명:
Carbocistein
동의어(영문):
SCMC;S-CMS;Lisil;Pectox;l.j.206;Mucocis;Mucofan;Mucolex;Mucotab;Mukinyl
CBNumber:
CB7467567
분자식:
C5H9NO4S
포뮬러 무게:
179.19
MOL 파일:
638-23-3.mol

카보시스테인 속성

녹는점
208-213 °C (dec.)
끓는 점
417.3±45.0 °C(Predicted)
알파
-31 º (c=1, 10% NaH2CO3)
밀도
1.315 (estimate)
굴절률
1.5216 (estimate)
저장 조건
2-8°C
산도 계수 (pKa)
2.06±0.10(Predicted)
물리적 상태
Amorphous Powder
색상
White to slightly off-white
수용성
SOLUBLE IN COLD WATER
Merck
14,1802
BRN
1725012
CAS 데이터베이스
638-23-3(CAS DataBase Reference)
EPA
L-Cysteine, S-(carboxymethyl)- (638-23-3)
안전
  • 위험 및 안전 성명
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 24/25-36-26
WGK 독일 2
RTECS 번호 AY4342000
TSCA Yes
HS 번호 29309090
독성 LD50 oral in rat: > 15gm/kg
기존화학 물질 KE-04830
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
NFPA 704
1
2 0

카보시스테인 MSDS


3-Carboxymethylthio-L-alanine

카보시스테인 C화학적 특성, 용도, 생산

화학적 성질

white to slightly off-white amorphous powder

Originator

Rhinathiol,Kramer,Switz.

용도

carbocysteine is an amino acid. It can be used to help control sebum production.

용도

Carbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).

용도

Labeled Carbocisteine, intended for use as an internal standard for the quantification of Carbocisteine by GC- or LC-mass spectrometry.

Manufacturing Process

There were placed 120g of L-cysteine (0.5 mol) in a 2 liter three-necked flask equipped with a stirrer thermometer and methanol/dry ice cooling and 1.5 liters of liquid ammonia were allowed to enter at -40°C. Then there were added under continuous cooling 50 g (2.17 mols) of sodium metal in portions of 1 to 2 g during the course of one hour. The end of the reaction was recognized by the continuation of the blue color. After the end of the reaction the excess sodium was destroyed by the addition of ammonium chloride and the ammonia vaporized at normal pressure. The residue was taken up in 500 ml of water and concentrated in a vacuum to 200 ml in order to remove residual ammonia, and again treated with 300 ml of water. The entire operations were carried out under a nitrogen atmosphere.
The aqueous solution of the disodium salt of L-cysteine obtained is then reacted at 20°C to 30°C under a nitrogen atmosphere in the course of 30 minutes with stirring with a solution of 104 g of chloroacetic acid (1.1 mols) and 4 g of sodium pyrosulfite in 200 ml of water. It is also allowed to post react for 15 minutes at 20°C, the solution clarified over activated carbon and the filtrate treated with 90 ml of concentrated hydrochloric acid to a pH of 2.5.
Thereby the S-carboxymethyl-L-cysteine precipitates out in crystalline form. The product is filtered off with suction, well stirred in 500 ml of water, again filtered with suction and dried in a vacuum at 70°C. The yield is 92% based on L-cysteine.

상표명

Loviscol (Wyeth-Ayerst); Mucofan (Wyeth-Ayerst).

Therapeutic Function

Mucolytic, Expectorant, Nasal antiinfective

Biochem/physiol Actions

S-Carboxymethyl-L-cysteine is studied as a small molecule mucoactive drug in vivo. These studies include analyzing the oxidative metabolism of S-carboxymethyl-L-cysteine by enzymes such as phenylalanine monooxygenase(s).

Safety Profile

contact. A riot control agent. When heated

카보시스테인 준비 용품 및 원자재

원자재

준비 용품


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