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우르솔산

우르솔산
우르솔산 구조식 이미지
카스 번호:
77-52-1
한글명:
우르솔산
동의어(한글):
우르솔산;우르솔릭애씨드
상품명:
Ursolic acid
동의어(영문):
MALOL;URSON;UrsoL;PRUNOL;Ursolic;NSC-4060;Masterin;Merotaine;Neoage UR;MICROMEROL
CBNumber:
CB7470516
분자식:
C30H48O3
포뮬러 무게:
456.71
MOL 파일:
77-52-1.mol

우르솔산 속성

녹는점
292 °C (dec.) (lit.)
알파
59 º (c=0.3, pyridine)
끓는 점
502.79°C (rough estimate)
밀도
1.0261 (rough estimate)
굴절률
1.4940 (estimate)
저장 조건
2-8°C
물리적 상태
Crystalline Powder or Needles
산도 계수 (pKa)
4.68±0.70(Predicted)
색상
White to off-white
수용성
insoluble
Merck
14,9890
BRN
2228563
CAS 데이터베이스
77-52-1(CAS DataBase Reference)
EPA
Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)- (77-52-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 24/25-36-26
WGK 독일 -
RTECS 번호 YU9520000
F 고인화성물질 10-23
HS 번호 29181990
유해 물질 데이터 77-52-1(Hazardous Substances Data)
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H413 장기적 영향에 의해 수생생물에 유해의 우려가 있음 수생 환경유해성 물질 - 만성 구분 4
예방조치문구:

우르솔산 C화학적 특성, 용도, 생산

화학적 성질

white to light yellow crystal powde

용도

A Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.

용도

ursolic acid helps maintain the look and feel of the skin, acts as a perfume and helps mask odor. Therapeutic benefits in skin care include anti-inflammatory activity. ursolic acid has demonstrated anti-microbial, anti-bacterial, and anti-fungal action as well.

용도

Ursolic Acid is a Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.Ursolic acid protects against muscle atrophy and boosts muscle growth (see also tomatidine T538500).

정의

ChEBI: A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.

일반 설명

Ursolic acid (UA) is a hydroxyl pentacyclic triterpenoic acid (HPTA), which exhibits anti-bacterial, anti-cancer, anti-oxidative and anti-inflammatory effects. It can also promote neuroregeneration after peripheral nerve injury. UA can enhance sleep duration by activating the GABAergic neurotransmitter system. [GABA= γ-aminobutyric acid]

Biochem/physiol Actions

Triterpenoid found in a variety of fruits, including apples. Cardioprotective and anti-tumor agent. Under study as a potential Alzheimer′s disease therapeutic due to its inhibitory effect on the interactions between amyloid-β and the CD36 receptor.

Anticancer Research

It is a triterpenoid, derived from basil, and suppresses the activation of NF-κB byinhibiting a kinase that activates NF-κB(IKK) (Aggarwal and Shishodia 2004). It suppresses tumorigenesis, tumor promotion, and angiogenesis by downregulationof the expression of lipoxygenases (LOX), MMP-9, and COX-2. It is reported toinduce apoptosis in breast cancer, melanoma, hepatoma, prostate cancer, andacute myelogenous leukemia by preventing replication of DNA, inhibition of proteintyrosine kinases, activation of caspases, induction of calcium release, anddownregulating apoptosis gene cellular inhibitor. Ursolic acid inhibits IκBαkinase activity, degradation of IκBα, phosphorylation, NF-κB-dependent reportergene expression, p65 nuclear translocation, and p65 phosphorylation. Inhibitionof NF-κB leads to the reduction of cyclin D1, COX-2, and MMP9 expression.This downregulates STAT-3 activation and its regulated gene products such ascyclin D1, Mcl-1, Bcl-xL, survivin, Bcl-2, and VEGF. It also induces the expressionof tyrosine phosphatase SHP-1 protein and of mRNA (Aggarwal et al. 2008;Hsu et al. 2004).

Cytotoxicity

IC50 (μg/mL): 6.7 (518A2), 5.3 (A2780), 7(A549), 6.4 (FaDu), 4.8 (HT29), 5.8(MCF-7), 8.5 (NIH3T3) (Wiemann et al.2016)
IC50 (μg/mL): 12.38 (MGC-803),17.12(HCT-116), 13.39 (T24), 13.81(HepG2), 16.36 (A549), >45.7 (HL-7702)(Hua et al. 2015).

우르솔산 준비 용품 및 원자재

원자재

준비 용품


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